Strengthening insights into host responses to mastitis infection in ruminants by combining heterogeneous microarray data sources

Genini, Sem; Badaoui, Bouabid; Sclep, Gert; Bishop, Stephen C; Waddington, Dave; Pinard van der Laan, Marie-Hélène; Klopp, Christophe; Cabau, Cédric; Seyfert, Hans-Martin; Petzl, Wolfram; Jensen, Kirsty; Glass, Elizabeth J; de Greeff, Astrid; Smith, Hilde E; Smits, Mari A; Olsaker, Ingrid; Boman, Guro M; Pisoni, Giuliano; Moroni, Paolo; Castiglioni, Bianca; Cremonesi, Paola; Del Corvo, Marcello; Foulon, Eliane; Foucras, Gilles; Rupp, Rachel; Giuffra, Elisabetta

doi:10.1186/1471-2164-12-225

Table 3 Dissimilar genes between E. coli and S. aureus infections in cattle

From: Strengthening insights into host responses to mastitis infection in ruminants by combining heterogeneous microarray data sources

Gene	Gene Name	E. coli shrunken centroid	S. aureus shrunken centroid
ABCG2	ATP-binding cassette, sub-family G WHITE, member 2	-1.007	0.671
IDH1	Isocitrate dehydrogenase 1 NADP+, soluble	-0.929	0.619
AGPAT1	1-acylglycerol-3-phosphate O-acyltransferase 1 lysophosphatidic acid acyltransferase, alpha	-0.894	0.596
PCGF1	Polycomb group ring finger 1	-0.795	0.53
GALNTL4	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 4	-0.52	0.346
CD74	CD74 molecule, major histocompatibility complex, class II invariant chain	-0.496	0.33
TMEM164	Transmembrane protein 164	-0.42	0.28
RHOF	Ras homolog gene family, member F	-0.391	0.261
MFSD4	Major facilitator superfamily domain containing 4	-0.263	0.175
DGCR2	DiGeorge syndrome critical region gene 2	-0.217	0.145
FEZ1	Fasciculation and elongation protein zeta 1 zygin I	-0.204	0.136
PAOX	Polyamine oxidase exo-N4-amino	-0.154	0.103
PMEPA1	Prostate transmembrane protein, androgen induced 1	-0.106	0.07
HIGD1B	HIG1 hypoxia inducible domain family, member 1B	-0.134	0.089
DNAJC12	DnaJ Hsp40 homolog, subfamily C, member 12	-0.132	0.088
VWF	Von Willebrand factor	-0.131	0.088
KIAA1467	KIAA1467	-0.131	0.087
SENP2	SUMO1/sentrin/SMT3 specific peptidase 2	-0.068	0.046
IGFBP5	Insulin-like growth factor binding protein 5	-0.06	0.04
SCP2	Sterol carrier protein 2	-0.018	0.012
NPAL2	NIPA-like domain containing 2	-0.009	0.006
LRRN3	Leucine rich repeat neuronal 3	0.732	-0.488
FKBP5	FK506 binding protein 5	0.7	-0.466
SLC38A7	Solute carrier family 38, member 7	0.641	-0.427
HSPD1	Heat shock 60 kDa protein 1 chaperonin	0.56	-0.373
GLUL	Glutamate-ammonia ligase glutamine synthetase	0.352	-0.235
CSDA	Cold shock domain protein A	0.174	-0.116
INO80E	INO80 complex subunit E	0.142	-0.095
SAT1	Spermidine/spermine N1-acetyltransferase 1	0.118	-0.079
PHB	Prohibitin	0.075	-0.05
STAT3	Signal transducer and activator of transcription 3 acute-phase response factor	0.061	-0.04
MAX	MYC associated factor X	0.051	-0.034
BTG1	B-cell translocation gene 1, anti-proliferative	0.033	-0.022
LCN2	Lipocalin 2	0.024	-0.016

List of the 34 most dissimilarly regulated genes identified with the PAMR software, showing opposite fold change responses during E. coli and S. aureus infections in cattle in vivo (experiment 1A, B, and C). For each gene, the PAMR shrunken centroid values (using a threshold parameter of 3.77) for the E. coli and the S. aureus experiments are reported. Twenty-one of the listed genes were up-regulated during infection with S. aureus, while 13 were up-regulated during E. coli infection.

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ISSN: 1471-2164

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