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Table 3 Minimum inhibitory concentration (MIC) test of mutant strains carrying disruptions in genes targeted based on their transcriptome profiles.

From: Genome-wide dynamics of a bacterial response to antibiotics that target the cell envelope

Strains Relevant genotype/comments MIC (μg/ml) Source/reference
   Vancomycin Bacitracin Moenomycin  
S. coelicolor A3(2) (M600) SCP1- SCP2- ~80 40-45 >300 Kieser et al. 2000 [81]
ΔSCO0600 (H1001) ΔsigB::apr SCP1- SCP2- 60-70 25-30 >300 This study
ΔSCO3356 (J2130) ΔsigE SCP1- SCP2- 60-70 35-40 >300 Paget et al. 1999 [20]
ΔSCO1513 (M570) ΔrelA SCP1- SCP2- 60-70 20-25 >300 Chakraburtty and Bibb. 1997 [23]
ΔSCO3089-3090 (H1003) ΔSCO3089-3090::apr SCP1- SCP2- 70-80 15-20 >300 This study
ΔSCO3110-3111 (H1002) ΔSCO3110-3111::apr SCP1- SCP2- 70-80 30-35 >300 This study
ΔSCO3089-3090 + ΔSCO3110-3111 (H1004) ΔSCO3089-3090 + 3110-3111::apr SCP1- SCP2- 70-80 <10 >300 This study
SCO4005::Tn (M900) SCO4005::Tn SCP1- SCP2- 70-80 25-30 >300 Hesketh et al. 2007 [21]
SCO5147::Tn (M903) SCO5147::Tn SCP1- SCP2- 80-90 40-45 >300 Hesketh et al. 2007 [21]
ΔSCO1875 (H1005) ΔSCO1875::apr SCP1- SCP2- <50 10-15 >300 This study
ΔSCO2608 (H1006) ΔSCO2608::apr SCP1- SCP2- 60-70 40-45 >300 This study
SCO2897::Tn (H1007) ΔSCO2897::Tn SCP1- SCP2- ~60 30-35 >300 This study
SCO3580::Tn (H1008) ΔSCO3580::Tn SCP1- SCP2- <50 40-45 >300 This study
SCO3771::Tn (H1009) ΔSCO3771::Tn SCP1- SCP2- <50 40-45 >300 This study
ΔSCO3847 (H1010) ΔSCO3847::apr SCP1- SCP2- ~60 40-45 >300 This study
SCO3901::Tn (H1011) ΔSCO3901::Tn SCP1- SCP2- ~60 40-45 >300 This study
ΔSCO4013 (H1012) ΔSCO4013::apr SCP1- SCP2- 70-80 40-45 >300 This study
SCO5039::Tn (H1013) ΔSCO5039::Tn SCP1- SCP2- 60-70 40-45 >300 This study
ΔSCO3397 (J3355) ΔSCO3397::apr SCP1- SCP2- <50 10-15 >300 This study