Figure 3

Higher-order network structures of DAR-FFCs. Repressor TFs with autoregulation are designated by ovals. Each straight black line terminated with -| indicates a TF-TF connection that constitutes a DAR-FFC and each circular black line terminated with -| indicates autoregulation. The higher-order network structures of the DAR-FFCs are individually depicted as blue triangles inside the corresponding TF-TF connections. The role assigned to a TF by each individual higher-order DAR-FFC is indicated with a symbol (X = originating regulator; Y = intermediary regulator; or Z = target) along the corresponding axis near the angle of the triangle. This schema illustrates that KLF12 always acts as an X (originating regulator) in all three higher-order DAR-FFCs in which it is involved, indicating that it may function as a 'higher-order originating regulator hub'.