Characterization of dosage effects. A) Entropy (Y-axis) vs. score of dosage effect (X-axis) for all genes, B) Histogram of scores for all 255 HSA21 genes accessible with the experiments under study, C) Distribution of genomic locations of the 324 candidate genes, D) Cytogenetic location of 77 HSA21 genes that show significant dosage effects for all experiments (blue line). Additionally, the same meta-analysis approach has been conducted with human (green line) and mouse (red line) data separately. The yellow line plots the relative number of HSA21 genes within each band (gene density). Y-axis shows percentage of significant genes with respect to all genes annotated for the chromosomal band.