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Figure 3 | BMC Genomics

Figure 3

From: Meta-analysis of heterogeneous Down Syndrome data reveals consistent genome-wide dosage effects related to neurological processes

Figure 3

Brain-related dosage effects. A) Venn diagram showing the overlap of the 324 significant genes with 623 genes identified by independent mouse studies related to brain phenotypes; B) RNA in situ hybridisations of BACH1 in postnatal mouse embryonic brain slices. C) In situ hybridisation of TTC3 in the same tissue. Images kindly provided by the HSA21 consortium ([4]; http://chr21.molgen.mpg.de/hsa21). D) Hierarchical clustering of 79 genes related to non-DS general brain disorders with the DS gene expression data sets. Clustering was performed with the J-Express 2009 software using Pearson correlation as similarity measure and complete linkage as update rule.

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BMC Genomics

ISSN: 1471-2164

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