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Table 1 Top thirty DS dosage effects on A) HSA21 and B) other chromosomes

From: Meta-analysis of heterogeneous Down Syndrome data reveals consistent genome-wide dosage effects related to neurological processes

A) Direct effects         
Ensembl HUGO Score Entropy Chromo-some Start
position
End
position
Band CNV
ENSG00000154734 ADAMTS1 18.487 4.083 chr21 28208606 28217728 q21.3  
ENSG00000159228 CBR1 17.518 4.509 chr21 37442239 37445464 q22.12  
ENSG00000159140 SON 15.920 4.712 chr21 34914924 34949812 q22.11  
ENSG00000142168 SOD1 15.817 4.372 chr21 33031935 33041244 q22.11  
ENSG00000182670 TTC3L, TTC3 15.637 4.542 chr21 38445526 38575413 q22.13  
ENSG00000142192 APP 15.489 4.412 chr21 27252861 27543446 q21.3  
ENSG00000159128 IFNGR2 15.006 4.640 chr21 34757299 34851655 q22.11  
ENSG00000182240 BACE2 14.156 4.140 chr21 42539728 42648524 q22.2  
ENSG00000156256 USP16 13.713 4.378 chr21 30396950 30426809 q21.3  
ENSG00000159131 GART 13.570 4.564 chr21 34870940 34915797 q22.11  
ENSG00000157540 DYRK1A 13.163 4.405 chr21 38739236 38887680 q22.13  
ENSG00000157557 ETS2 13.088 4.440 chr21 40177231 40196879 q22.2  
ENSG00000159231 CBR3 12.185 3.954 chr21 37507210 37518864 q22.12 YES
ENSG00000159082 SYNJ1 11.880 4.284 chr21 33997269 34100359 q22.11  
ENSG00000142188 TMEM50B 11.516 3.803 chr21 34804792 34853499 q22.11 YES
ENSG00000159110 IFNAR2 11.280 4.360 chr21 34602206 34656082 q22.11  
ENSG00000157538 DSCR3 11.254 4.316 chr21 38591910 38640262 q22.13  
ENSG00000157601 MX1 10.976 3.545 chr21 42792231 42831141 q22.3  
ENSG00000159267 HLCS 10.764 4.183 chr21 38123493 38362536 q22.13 YES
ENSG00000159200 RCAN1 10.719 3.356 chr21 35885440 35987441 q22.12  
ENSG00000159147 DONSON 10.435 4.295 chr21 34947783 34961014 q22.11  
ENSG00000156261 CCT8 10.361 4.560 chr21 30428126 30446118 q21.3  
ENSG00000183486 MX2 10.179 3.598 chr21 42733870 42781317 q22.3  
ENSG00000154727 GABPA 9.936 4.032 chr21 27106881 27144771 q21.3  
ENSG00000160200 CBS 9.284 3.907 chr21 44473301 44497053 q22.3  
ENSG00000159216 RUNX1 9.129 3.783 chr21 36160098 37357047 q22.12  
ENSG00000183527 PSMG1 8.903 3.733 chr21 40546695 40555777 q22.2  
ENSG00000182093 WRB 8.837 4.149 chr21 40752170 40800454 q22.2  
ENSG00000154736 ADAMTS5 8.746 4.221 chr21 28290231 28338832 q21.3  
ENSG00000159197 KCNE2 8.654 3.660 chr21 35736323 35743440 q22.11 YES
B) Indirect effects         
Ensembl HUGO Score Entropy Chromo-some Start
position
End
position
Band CNV
ENSG00000117289 TXNIP 8.790 3.281 chr1 145438469 145442635 q21.1 YES
ENSG00000133110 POSTN 8.301 2.437 chr13 38136722 38172981 q13.3 YES
ENSG00000118785 SPP1 7.232 3.159 chr4 88896802 88904563 q22.1  
ENSG00000113140 SPARC 7.035 3.338 chr5 151040657 151066726 q33.1  
ENSG00000125968 ID1 6.987 3.164 chr20 30193086 30194318 q11.21  
ENSG00000136235 GPNMB 6.943 2.047 chr7 23275586 23314727 p15.3  
ENSG00000171951 SCG2 6.747 2.950 chr2 224461658 224467221 q36.1  
ENSG00000135821 GLUL 6.604 3.702 chr1 182350839 182361341 q25.3  
ENSG00000123610 TNFAIP6 6.575 2.377 chr2 152214106 152236560 q23.3  
ENSG00000118523 CTGF 6.567 2.996 chr6 132269316 132272513 q23.2  
ENSG00000168209 DDIT4 6.477 3.318 chr10 74033678 74035794 q22.1  
ENSG00000162407 PPAP2B 6.350 3.343 chr1 56960419 57110974 p32.2  
ENSG00000038427 VCAN 6.240 2.958 chr5 82767284 82878122 q14.2  
ENSG00000151491 EPS8 6.194 3.143 chr12 15773076 15942510 p12.3  
ENSG00000189067 LITAF 6.185 3.255 chr16 11641582 11680806 p13.13  
ENSG00000164692 COL1A2 6.148 2.852 chr7 94023873 94060544 q21.3  
ENSG00000204388 HSPA1B 6.109 2.550 chr6 31795688 31798031 p21.33  
ENSG00000162692 VCAM1 6.012 2.533 chr1 101185305 101204601 p21.2  
ENSG00000154096 THY1 5.974 3.244 chr11 119288888 119293854 q23.3  
ENSG00000135919 SERPINE2 5.904 3.048 chr2 224839765 224904036 q36.1  
ENSG00000172201 ID4 5.887 3.037 chr6 19837617 19840915 p22.3  
ENSG00000114315 HES1 5.884 2.874 chr3 193853934 193856521 q29  
ENSG00000172893 DHCR7 5.883 3.441 chr11 71145457 71159477 q13.4  
ENSG00000204262 COL5A2 5.857 3.174 chr2 189896622 190044605 q32.2  
ENSG00000149257 SERPINH1 5.846 3.146 chr11 75273170 75283844 q13.5  
ENSG00000176697 BDNF 5.805 2.416 chr11 27676440 27743605 p14.1  
ENSG00000182551 ADI1 5.782 3.081 chr2 3501693 3523507 p25.3  
ENSG00000079739 PGM1 5.661 3.251 chr1 64058947 64125916 p31.3  
ENSG00000108821 COL1A1 5.527 3.004 chr17 48260650 48278993 q21.33  
ENSG00000187498 COL4A1 5.514 3.396 chr13 110801318 110959496 q34