Table 2 Enriched neuropathological pathways.
PATHWAY (Source Database) | Pathway size | P-value | FWER P-value | Genes on HSA21 | HSA21 Interactors | Others |
|---|---|---|---|---|---|---|
HUNTINGTONS DISEASE (KEGG) | 159 | 0 | 0 | SOD1; DONSON | REST | BDNF; SOD2 |
ALZHEIMERS DISEASE (KEGG) | 147 | 0 | 0 | APP; BACE2; DONSON | PPP3CA; GSK3B | CAPN2 |
SIGNALLING BY NGF (REACTOME) | 209 | 0 | 0 | ITSN1; TIAM1 | PIK3R1; GSK3B | RPS6KA2; RAP1A; KRAS |
AXON GUIDANCE (REACTOME) | 256 | 0 | 0 | COL6A2 | GSK3B;COL1A1; COL1A2; COL4A1; COL4A2 | COL5A2; DPYSL3; RPS6KA2; LAMB1; COL3A1; COL5A1; ALCAM; KRAS |
PARKINSONS DISEASE (KEGG) | 105 | 0 | 0 | DONSON | UBE2G2 | |
P75(NTR)-MEDIATED SIGNALING (PID) | 68 | 0 | 0 | APP | PIK3R1 | BDNF |
NOTCH (NETPATH) | 61 | 0 | 0 | APP | PIK3R1; GSK3B | |
NEUROTROPHIN SIGNALING PATHWAY (KEGG) | 121 | 0 | 0 | PIK3R1; GSK3B | BDNF; RPS6KA2; RAP1A; KRAS | |
NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE (REACTOME) | 127 | 0 | 0 | PIK3R1; GSK3B | RPS6KA2; RAP1A; KRAS | |
MEMBRANE TRAFFICKING (REACTOME) | 87 | 0 | 0 | TJP1 | GJA1; COPG | |
NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING (PID) | 60 | 0 | 0 | TIAM1 | PIK3R1 | BDNF; RAP1A; KRAS |
EPO SIGNALING (INOH) | 180 | 0 | 0 | PIK3R1; GSK3B | ||
CDC42 SIGNALING EVENTS (PID) | 68 | 0 | 0 | TIAM1 | PIK3R1; GSK3B | EPS8; YES1 |
L1CAM INTERACTIONS (REACTOME) | 93 | 0 | 0 | LAMB1; ALCAM1; RPS6KA2 |