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Table 2 Enriched neuropathological pathways.

From: Meta-analysis of heterogeneous Down Syndrome data reveals consistent genome-wide dosage effects related to neurological processes

PATHWAY (Source Database) Pathway
size
P-value FWER P-value Genes on HSA21 HSA21 Interactors Others
HUNTINGTONS DISEASE (KEGG) 159 0 0 SOD1; DONSON REST BDNF; SOD2
ALZHEIMERS DISEASE (KEGG) 147 0 0 APP; BACE2; DONSON PPP3CA; GSK3B CAPN2
SIGNALLING BY NGF (REACTOME) 209 0 0 ITSN1; TIAM1 PIK3R1; GSK3B RPS6KA2; RAP1A; KRAS
AXON GUIDANCE (REACTOME) 256 0 0 COL6A2 GSK3B;COL1A1; COL1A2; COL4A1; COL4A2 COL5A2; DPYSL3; RPS6KA2; LAMB1; COL3A1; COL5A1; ALCAM; KRAS
PARKINSONS DISEASE (KEGG) 105 0 0 DONSON   UBE2G2
P75(NTR)-MEDIATED SIGNALING (PID) 68 0 0 APP PIK3R1 BDNF
NOTCH (NETPATH) 61 0 0 APP PIK3R1; GSK3B  
NEUROTROPHIN SIGNALING PATHWAY (KEGG) 121 0 0   PIK3R1; GSK3B BDNF; RPS6KA2; RAP1A; KRAS
NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE (REACTOME) 127 0 0   PIK3R1; GSK3B RPS6KA2; RAP1A; KRAS
MEMBRANE TRAFFICKING (REACTOME) 87 0 0   TJP1 GJA1; COPG
NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING (PID) 60 0 0 TIAM1 PIK3R1 BDNF; RAP1A; KRAS
EPO SIGNALING (INOH) 180 0 0   PIK3R1; GSK3B  
CDC42 SIGNALING EVENTS (PID) 68 0 0 TIAM1 PIK3R1; GSK3B EPS8; YES1
L1CAM INTERACTIONS (REACTOME) 93 0 0    LAMB1; ALCAM1; RPS6KA2