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Figure 4 | BMC Genomics

Figure 4

From: Genome-wide patterns of promoter sharing and co-expression in bovine skeletal muscle

Figure 4

TF network for bovine skeletal muscle. (A) Overall view of the 1,395 connections among 333 TFs; (B) Subnetwork spanned by the first neighbors of the 10 most connected TFs (GATA2, MAZ, NFE2L1, NFKB1, NKX25, NKX61, PAX4, PRRX2, TFCP2, and ZBTB7B), details of which are listed in Table 3; (C) Subnetwork of module-specific and muscle-expressed TFs; (D) Network among TFs with absolute correlation (r) >0.9 and number of common TGs (N) >100. Black and red edges correspond to positive and negative correlations, respectively. The network reveals the central role of TGIF1 which also contains a binding motif in the promoter region of myostatin (MSTN). Colors represent functional modules: cell cycle (green), fat (yellow), immune (purple), mitochondria (cyan), and muscle/glycolysis (red). Big and small nodes represent TFs with and without detectable expression in muscle, respectively.

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