Skip to main content

Table 2 The number of DS-DMRs in different tissues

From: Genome-wide survey reveals dynamic widespread tissue-specific changes in DNA methylation during development

  Total Adjusted# %1 CpGi-Prom %2 non-CpGi-Prom %2 Intra-genic CpGi %2 Inter-genic CpGi %2
Brain:
Common 1903 NA ND 182 9.6 1018 53.5 493 25.9 210 11.0
E15_uniq 533 533 27.5 105 19.7 359 67.4 35 6.6 34 6.4
E15+NB 490 509 25.3 66 13.5 368 75.1 29 5.9 27 5.5
NB_uniq 370 400 19.1 55 14.9 248 67.0 42 11.4 25 6.8
AD_uniq 408 532 21.1 94 23.0 233 57.1 52 12.7 29 7.1
NB+AD 70 82 3.6 5 7.1 40 57.1 16 22.9 9 12.9
E15+AD 65 77 3.4 11 16.9 46 70.8 7 10.8 1 1.5
Total* 1936 2132 100.0 336 15.2 1294 62.6 181 13.9 125 8.4
UnMe-AD** 1393 1442 72.0 226 16.2 975 70.0 106 7.6 86 6.2
Me-AD*** 543 691 28.0 110 20.3 319 58.8 75 13.8 39 7.2
Heart:
Common 1844 NA ND 218 11.8 946 51.3 491 26.6 189 10.2
E15_uniq 46 81 6.9 27 58.7 8 17.4 2 4.3 9 19.6
E15+NB 87 125 13.0 17 19.5 61 70.1 4 4.6 5 5.7
NB_uniq 93 112 13.9 12 12.9 64 68.8 7 7.5 10 10.8
AD_uniq 172 172 25.6 45 26.2 83 48.3 33 19.2 11 6.4
NB+AD 246 253 36.7 44 17.9 132 53.7 54 22.0 16 6.5
E15+AD 27 34 4.0 6 22.2 15 55.6 5 18.5 1 3.7
Total* 671 777 100.0 151 22.4 363 54.1 105 15.6 52 7.7
UnMe-AD** 226 318 33.7 56 24.8 133 58.8 13 5.8 24 10.6
Me-AD*** 445 459 66.3 95 21.3 230 51.7 92 20.7 28 6.3
Liver:
Common 1497 NA ND 141 9.4 726 48.5 425 28.4 205 13.7
E15_uniq 117 119 4.9 25 21.4 74 63.2 10 8.5 8 6.8
E15+NB 1419 1431 60.0 198 14.0 1034 72.9 125 8.8 62 4.4
NB_uniq 147 147 6.2 24 16.3 109 74.1 8 5.4 6 4.1
AD_uniq 468 813 19.7 70 15.0 322 68.8 45 9.6 31 6.6
NB+AD 36 46 1.5 2 5.6 30 83.3 3 8.3 1 2.8
E15+AD 194 249 8.1 13 6.7 130 67.0 31 16.0 20 10.3
Total* 2381 2804 100.0 332 13.9 1699 71.4 222 9.3 128 5.4
UnMe-AD** 1683 1696 70.7 247 14.7 1217 72.3 143 8.5 76 4.5
Me AD*** 698 1107 29.3 85 12. 482 69.1 79 11.3 52 7.4
Testis:            
Common 570 NA ND 20 3.5 363 63.7 148 26.0 39 6.8
E15_uniq 272 380 6.3 105 38.6 101 37.1 33 12.1 33 12.1
E15+NB 939 1094 22.0 193 20.6 480 51.1 157 16.7 109 11.6
NB_uniq 798 789 18.4 231 28.9 391 49.0 86 10.8 90 11.3
AD_uniq 2214 2336 50.9 71 3.2 1908 86.2 165 7.5 70 3.2
NB+AD 63 65 1.4 3 4.8 48 76.2 9 14.3 3 4.8
E15+AD 62 91 1.4 5 8.1 38 61.3 14 22.6 5 8.1
Total 4348 4755 100.0 608 14.0 2966 68.2 464 10.7 310 7.1
UnMe-AD** 2009 2263 40.8 529 26.3 972 48.4 276 13.7 232 11.5
Me-AD*** 2339 2493 47.6 79 3.4 1994 85.3 188 8.0 78 3.3
Grand Total:
Common 5814 NA ND 561 9.6 3053 52.5 1557 26.8 643 11.1
DS-DMRs 9336 10469 100.0 1427 15.3 6322 67.7 972 10.4 615 6.6
UnMe-AD** 5311 5719 56.9 1058 19.9 3297 62.1 538 10.1 418 7.9
Me-AD*** 4025 4750 43.1 369 9.2 3025 75.2 434 10.8 197 4.9
  1. %1: percentage is based on the row total vs. total DMRs; %2: percentage is based on the total of DMRs in the row; Total*: Stage specific; UnMe-AD**: unmethylated in AD but methylated in E15 and/or NB; Me-AD***: methylated in Adult but unmethylated in E15 and/or NB; Adjusted#: number of DMRs adjusted based on the adjusted coefficiency between the duplicated samples.