Figure 5

siRNA knock-down of miR-30a-3p. (Panel A) A composite plot summarising the enrichment scoring of all possible hexameric queries given the associated hsa-miR-30a-3p differential expression profile. The complement of the hsa-miR-30a-3p seed motif (TTTACA) is highlighted in red. All other higher scoring hexamer profiles represent uncharacterised AT-rich hexamers. Also note the enrichment scores of greater than 100 with a number of AT-rich motifs among the up-regulated transcripts located on the left of the plot. (Panel B) This plot summarises the enrichment profile of the highest scoring hexamer (highlighted in turquoise in the composite plot of Panel A) following hsa-mir-30a-3p transfection. SBSE analysis estimates this motif (TAATTT) to be enriched in the up-regulated transcripts and the maximum enrichment score is therefore located to the left of the plot.