Figure 1

Phylogenetic tree of aspartic proteinases (AP) from Phytophthora infestans (Pi), Phytophthora sojae (Ps) and Phytophthora ramorum (Pr). The tree was generated from sequences of the mature enzyme regions and was rooted at the pig pepsin (PepA_PIG) node. ScPEP4p and NcPEP4 are the respective vacuolar APs from Saccharomyces cerevisiae and Neurospora crassa. Ath_CDR1 and Ath-NP_199124 are respectively C-terminally unextended and extended APs from Arabidopsis thaliana. Pt-XP_002180775 is from Phaeodactylum tricornutum. Nepenthesin 1, plasmepsin V and human BACE/BACE2 are as described in the text. Alignment of entries clustering in clades 1 and 2 (in black characters) is shown in Figure 2; alignment of entries clustering in clade 3 (in red characters) is shown in Figure 3; alignment of entries clustering in clade 4 (in green characters) is shown in Figure 4; alignment of entries clustering in clade 5 (in blue characters) is shown in Figure 5.