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Table 3 Comparison of clinical signs with percentages between Cohen syndrome patients and seven TNS affected Border collies.

From: A canine model of Cohen syndrome: Trapped Neutrophil Syndrome

Clinical signs

Cohen Syndrome (%)†

TNS (%)

typical facies

81*

43

slender extremities

91

86

mental retardation

99

43

microcephaly

53

71

infantile hypotonia

86

71

developmental delay

81

86

delayed puberty

41

86

short stature

47

60‡

truncal obesity

65

0

neutropenia

75§

100

myopia

44

n/a

cataracts

64

n/a

  1. n/a - not available
  2. * average for clinical signs: short philtrum, high narrow palate, prominent nasal bridge and prominent central upper incisors
  3. † Data summarised from Taban et al. [23] where the number of individuals for each category varies depending on what has been reported in the literature
  4. ‡ out of five dogs as two died before reaching maturity
  5. § data summarised from Hennies et al. [24]; Kivitie-Kallio and Norio [25]; Chandler et al. [26]; Kolehmainen et al. [15]; Bugiani et al. [27]; Kivitie-Kallio et al. [12]; and Seifert et al. [14].