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Table 3 Comparison of clinical signs with percentages between Cohen syndrome patients and seven TNS affected Border collies.

From: A canine model of Cohen syndrome: Trapped Neutrophil Syndrome

Clinical signs Cohen Syndrome (%)† TNS (%)
typical facies 81* 43
slender extremities 91 86
mental retardation 99 43
microcephaly 53 71
infantile hypotonia 86 71
developmental delay 81 86
delayed puberty 41 86
short stature 47 60‡
truncal obesity 65 0
neutropenia 75§ 100
myopia 44 n/a
cataracts 64 n/a
  1. n/a - not available
  2. * average for clinical signs: short philtrum, high narrow palate, prominent nasal bridge and prominent central upper incisors
  3. † Data summarised from Taban et al. [23] where the number of individuals for each category varies depending on what has been reported in the literature
  4. ‡ out of five dogs as two died before reaching maturity
  5. § data summarised from Hennies et al. [24]; Kivitie-Kallio and Norio [25]; Chandler et al. [26]; Kolehmainen et al. [15]; Bugiani et al. [27]; Kivitie-Kallio et al. [12]; and Seifert et al. [14].