Table 1 Genes under diversifying selection identified by both models
From: Genes in the terminal regions of orthopoxvirus genomes experience adaptive molecular evolution
ORF Number | Gene Family Name | Category | VACV-Cop ORF | Specific Function | Virion |
|---|---|---|---|---|---|
021 | EGF_Growth factor | Host Response Modifier | C11R | EGF homolog with mitogenic activity | No |
024 | IL_18_BP (Bsh_D7L) | Host Response Modifier | n/a | Inhibition of IL-18 activity | No |
035 | Kelch_like_ (Cop_C2L) | Host Response Modifier | C2L | Unknown | No |
036 | Unknown (Cop_C1L) | Unknown | C1L | Unknown | No |
046 | Unknown (Cop_K7R) | Entry/Exit | K7R | inhibitor of pattern recognition receptor signalling pathway | No |
048 | Apoptosis inhibitor (mitochondrial associated) | Host Response Modifier | F1L | localizes to mitochondria and inhibits apoptosis | No |
054 | Unknown (Cop_F6L) | Unknown | F6L | Unknown | No |
055 | Unknown (Cop_F7L) | Unknown | F7L | Unknown | No |
056 | Cytoplasmic protein (Cop_F8L) | Unknown | F8L | Cytoplasmic localization, unknown function | No |
063 | Unknown (Cop_F14L) | Unknown | F14L | Unknown | No |
129 | Carbonic anhydrase Virion | Entry/Exit | D8L | Binds Chondroitin Sulfate on cell surface | Yes |
140 | Core_protein (Cop_A4L) | Structure/Assembly | A4L | associated with virion core and membranes | Yes |
145 | Membrane protein (Cop_A9L) | Structure/Assembly | A9L | located on virion membrane, essential for morphogenesis | Yes |
162 | RNA pol 132 (RPO132) | RNA metabolism | A24R | Component of RNA polymerase | Yes |
171 | Unknown (YMTV_120.5L) | Unknown | A30.5L | Unknown | No |
172 | Unknown (Cop_A31R) | Host Response Modifier | A31R | Unknown | Yes |
182 | Semaphorin | Host Response Modifier | A39R | Induces IL-6 and IL-8 secretion from monocytes | No |
191 | Unknown (Cop_A47L) | Unknown | A47L | Unknown | No |
192 | Thymidylate kinase | DNA metabolism | A48R | Thymidylate kinase activity | No |
200 | Hemagglutinin | Host Response Modifier | A56R | prevents cell-cell fusion, present on EEV and cell surface | Yes |
203 | Schlafen (Cop_B2R) | Host Response Modifier | B2R | Virulence factor in CMLV | No |
204 | Ankyrin (Cop_B4R) | Unknown | B4R | Unknown | No |
212 | Ser_Thr_Kinase (Cop_B12R) | Unknown | B12R | Unknown | No |
215 | IL_1_beta receptor | Host Response Modifier | B15R | Inhibits IL-1 beta activity | No |
216 | Unknown (Cop_B17L) | Unknown | B17R | Unknown | No |