Effect of L-cysteine deprivation on expression of the genes involved in sulfur-containing amino acid metabolism. A) General scheme of sulfur-containing amino acid metabolism in E. histolytica. Abbreviations: CS, cysteine synthase; SAT, serine O-acetyltransferase; PGDH, phosphoglycerate dehydrogenase; MGL, methionine γ-lyase; MAT, methionine adenosyl-transferase; MT, methyl-transferase; SAHH, S-adenosylhomocysteine hydrolase; NifS, cysteine desulfurase; PSAT, phosphoserine aminotransferase; PSP, phosphoserine phosphatase; OAS; O-acetylserine; SMC, S-methylcysteine; SAH, S-adenosylhomocysteine; SAM, S-adenosyltransferase; P-Ser, O-phosphoserine; 3-PGA, 3-phosphoglycerate. B) Modulation of transcripts encoding enzymes involved in sulfur containing amino acid metabolism. Gene IDs: CS1, EHI_171750; CS2, EHI_160930; CS3, EHI_060340; MAT, 70.m00173; MGL1, EHI_144610; MGL2, EHI_142250; NifS; EHI_136380; PGDH, EHI_060860; PSAT, EHI_026360; SAHH, EHI_068250; SAT2, EHI_021570; SAT3, EHI_153430.