Figure 3
Orthologies of BMP signaling components based on maximum likelihood gene trees using predicted amino acid sequences. (A) TGFß ligands (substitution model DCMut+i+g+g); (B) TGFβ type I and type II receptors (substitution model WAG+i+g+f); (C) SMAD family (substitution model LG+g+f); (D) Metalloproteases related to Tld and Tok (substitution model Dayhoff+g+f); (E) Kekkon family (substitution model LG+i+g+f); (F) Crossveinless family (substitution model Dayhoff+i+g+f); (G) DAN family (substitution model Dayhoff+i+g+f); scale bars indicate estimated changes/position. BeetleBase (T. castaneum) and GenBank accession numbers (all others): (A) Act (Activin-β; NM_143685), Tca Act (TC015806), Tca BMP10 (TC006506), Daw (dawdle; NM_078737), Tca Daw (TC04297), Dpp (decapentaplegic; NM_057963), Eba Dpp (JN006972), Tca Dpp (TC008466), Gbb (glass bottom boat; NM_057992), Eba Gbb (JN006973), Tca Gbb1 (TC014017), Tca Gbb2 (TC014018), Mav (maverick; NM_079887.2), Tca Mav (TC004299), Myo (myoglianin; NM_166786) Tca Myo (TC015805), Scw (screw; NM_080124.4), Eba Scw (JN006978); (B) Babo (baboon; NM_057652), Eba Babo (JN006969), Tca Babo (TC003240), Put (punt; NM_169591), Eba Put (JN006976), Tca Put (TC011357), Sax (saxophone; NM_078928), Eba Sax (JN006977), Tca Sax (TC015984), Tkv (thickveins; NM_175975), Eba Tkv (JN006980), Tca Tkv (TC006474), Wit (wishful thinking; NM_079953), Eba Wit (JN006986), Tca Wit (TC009314); (C) Mad (mothers against dpp; NM_057669), Eba Mad (JN006974), Tca Mad (TC014924), Med (Medea; NM_079871), Eba Med (JN006975), Tca Med (TC010848), Smox (smad on X; NM_078524), Eba Smox (JN006979), Tca Smox (TC010162); (D) Tld (tolloid; NM_079763), Eba Tld (JN006985), Tok (tolkin; NM_057531), Tca Tok (TC011197); (E) Kek1 (kekkon-1; NM_078835), Kek2 (NM_078827), Tca Kek2 (TC007053), Tca Kek2' (TC008448), Eba Kek2 (JN006983), Kek3 (NM_078851), Tca Kek3 (TC007226), Kek4 (NM_135771), Tca Kek4 (TC007110), Tca Kek4' (TC008070), Kek5 (NM_133154), Eba Kek5 (JN006984); (F) Cv (crossveinless; NM_080525), Eba Cv (JN006982), Eba Cv-like (JN006970), Srw (shrew; NM_139629), Tsg (twisted gastrulation; NM_078580), Eba Tsg (JN006981), Tca Tsg (TC003620); (G) Mmu Cerberus (Mus musculus; NM_009887), Mmu Dante (NM_201227), Mmu Gremlin (NM_011824), Tca Gremlin (TC007044), Eba DAN (JN006971), Mmu DAN (NM_008675.2), Tca DAN (TC014861).