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Table 2 Significantly altered mRNA and proteins related to carbohydrate metabolism

From: Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes

  Transcriptomics Proteomics
Glycogenesis Adj. p-value Fold change Adj. p-value Fold change
Glucokinase (Gck) 4.84E-03 1.8   
Glucan (1,4-alpha-), branching enzyme 1 (Gbe1) 3.03E-03 2.3 2.98E-05 1.5
Glycogenolysis     
Amylo-1,6-glucosidase, 4-alpha-glucanotransferase (Agl) 6.05E-03 1.8   
Protein phosphatase 1, regulatory (inhibitor) subunit 2 (Ppp1r2) 4.00E-03 1.4   
Glycogen phosphorylase, liver form (Pygl)    1.41E-03 1.2
Glycolysis     
Glucokinase (Gck) 4.84E-03 1.8   
Aldolase C, fructose-bisphosphate (Aldoc) 8.48E-03 1.9   
Alpha-enolase (Eno1)    1.62E-03 1.1
Pyruvate kinase, liver (Pklr)    3.28E-05 1.5
Fructose-bisphosphate aldolase B (Aldob)    2.59E-03 1.2
Glucose-6-phosphate isomerase (Gpi)    6.90E-05 1.2
Glyceraldehyde-3-phosphate dehydrogenase (Gapdh)    1.10E-03 -1.2
Gluconeogenesis     
Fructose bisphosphatase 1 (Fbp1) 3.35E-03 -1.9 4.26E-06 -1.4
Phosphoenolpyruvate carboxykinase 1, cytosolic (Pck1) 3.22E-03 -10.2   
TCA Cycle-related     
Pyruvate dehydrogenase complex component E2 (Dlat) 4.48E-03 1.8   
Pyruvate dehydrogenase kinase, isoenzyme 1 (Pdk1) 7.73E-03 2.0   
Pyruvate dehyrogenase phosphatase catalytic subunit 2 (Pdp2) 6.96E-03 -1.4   
Fumarate hydratase (Fh1) 2.02E-03 -1.6 3.78E-03 -1.2
Succinate dehydrogenase flavoprotein subunit, mitochondrial (Sdha) 3.05E-03 -1.3   
2-oxoglutarate dehydrogenase complex component E2 (Dlst)    2.53E-03 -1.2