Table 3 Significantly Altered mRNA and Proteins related to Amino Acid Catabolism
| Â | Transcriptomics | Proteomics | ||
|---|---|---|---|---|
Amino Acid Metabolism | Adj. p-value | Fold change | Adj. p-value | Fold change |
Alanine-glyoxylate aminotransferase (Agxt)* | 1.02E-02 | -1.8 | 1.82E-03 | -1.2 |
Cystathionase (cystathionine gamma-lyase) (Cth)* | 1.66E-02 | -1.5 | 8.36E-04 | -1.4 |
Glutamic-oxaloacetic transaminase 1, soluble (Got1)* | 9.42E-03 | -2.8 | 1.05E-05 | -2.1 |
Glutamic-pyruvate transaminase (Gpt)* | 1.42E-02 | -1.6 | 9.90E-04 | -1.3 |
Glutamic pyruvate transaminase 2 (Gpt2)* | 1.52E-02 | -1.5 | Â | Â |
Ornithine aminotransferase (Oat)* | 1.08E-03 | -5.0 | 2.52E-06 | -2.3 |
Prolyl 4-hydroxylase, beta polypeptide (P4hb)* | 1.62E-02 | -1.4 | Â | Â |
Serine dehydratase (Sds)* | 1.85E-02 | -2.6 | Â | Â |
Serine dehydratase-like (Sdsl)* | 1.89E-02 | -1.5 | Â | Â |
Homogentisate 1,2-dioxygenase (Hgd)*^ | 4.28E-03 | -1.7 | 2.41E-06 | -1.4 |
Aminoadipate-semialdehyde synthase (Aass)^ | 1.00E-02 | -1.5 | Â | Â |
3-hydroxyanthranilate 3,4-dioxygenase (Haao)^ | 4.33E-04 | -2.4 | 4.57E-05 | -1.4 |
Isovaleryl Coenzyme A dehydrogenase (Ivd)^ | 3.81E-03 | -1.8 | Â | Â |
Kynureninase (L-kynurenine hydrolase) (Kynu)^ | 1.61E-02 | -2.1 | Â | Â |
Tyrosine aminotransferase (Tat)^ | 1.72E-02 | -2.2 | Â | Â |
Tryptophan 2,3-dioxygenase (Tdo2)^ | 3.03E-03 | -1.9 | Â | Â |
Alanyl-tRNA synthetase (Aars) | 8.80E-03 | -1.3 | Â | Â |
δ-aminolevulinate synthase 2 (Alas2) | 1.11E-02 | -2.9 |  |  |
Aldehyde dehydrogenase 4 family, member A1 (Aldh4a1) | 1.28E-02 | -1.4 | Â | Â |
Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (Cad) | 1.99E-02 | -1.3 | Â | Â |
Cytochrome P450, family 7, subfamily B, polypeptide 1 (Cyp7b1) | 3.45E-03 | -3.1 | Â | Â |
Dopa decarboxylase (aromatic L-amino acid decarboxylase) (Ddc) | 1.02E-02 | -1.9 | Â | Â |
Formiminotransferase cyclodeaminase (Ftcd) | 2.88E-03 | -1.6 | 3.52E-03 | -1.3 |
Glycine N-methyltransferase (Gnmt) | 1.05E-02 | -1.5 | Â | Â |
Sarcosine dehydrogenase, mitochondrial (Sardh) | Â | Â | 3.73E-03 | -1.2 |
Glucosamine-phosphate N-acetyltransferase 1 (Gnpnat1) | 1.11E-02 | -1.2 | Â | Â |
Leucine aminopeptidase 3 (Lap3) | 3.45E-03 | -1.4 | 6.01E-06 | -1.2 |
Methyltransferase like 7B (Mettl7b) | 2.02E-03 | -1.6 | Â | Â |
4-hydroxyphenylpyruvate dioxygenase (Hpd) | Â | Â | 9.17E-04 | -1.3 |
Phenylalanine hydroxylase (Pah) | 1.70E-02 | -1.2 | 3.07E-05 | -1.5 |
Branched-chain alpha-keto acid dehydrogenase complex component E2 (Dbt) | Â | Â | 2.29E-03 | -1.3 |
4-aminobutyrate aminotransferase, mitochondrial (Abat) | Â | Â | 1.10E-03 | -1.2 |
Urea Cycle & Metabolism of Amino Groups | Â | Â | Â | Â |
Mitochondrial ornithine transporter 1 (Slc25a15) | 9.92E-03 | -1.4 | Â | Â |
Argininosuccinate synthetase 1 (Ass1)* | 1.62E-02 | -1.5 | 1.25E-07 | -1.6 |
Argininosuccinate lyase (Asl) | Â | Â | 1.35E-03 | -1.2 |
Arginase 1 (Arg1) | Â | Â | 1.53E-03 | -1.2 |
Glutamate-ammonia ligase, Glutamine synthetase (Glul)* | Â | Â | 1.04E-03 | 1.3 |
Carbonic anhydrase3 (C a3) | Â | Â | 3.78E-03 | -1.18 |