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Table 3 Significantly Altered mRNA and Proteins related to Amino Acid Catabolism

From: Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes

  Transcriptomics Proteomics
Amino Acid Metabolism Adj. p-value Fold change Adj. p-value Fold change
Alanine-glyoxylate aminotransferase (Agxt)* 1.02E-02 -1.8 1.82E-03 -1.2
Cystathionase (cystathionine gamma-lyase) (Cth)* 1.66E-02 -1.5 8.36E-04 -1.4
Glutamic-oxaloacetic transaminase 1, soluble (Got1)* 9.42E-03 -2.8 1.05E-05 -2.1
Glutamic-pyruvate transaminase (Gpt)* 1.42E-02 -1.6 9.90E-04 -1.3
Glutamic pyruvate transaminase 2 (Gpt2)* 1.52E-02 -1.5   
Ornithine aminotransferase (Oat)* 1.08E-03 -5.0 2.52E-06 -2.3
Prolyl 4-hydroxylase, beta polypeptide (P4hb)* 1.62E-02 -1.4   
Serine dehydratase (Sds)* 1.85E-02 -2.6   
Serine dehydratase-like (Sdsl)* 1.89E-02 -1.5   
Homogentisate 1,2-dioxygenase (Hgd)*^ 4.28E-03 -1.7 2.41E-06 -1.4
Aminoadipate-semialdehyde synthase (Aass)^ 1.00E-02 -1.5   
3-hydroxyanthranilate 3,4-dioxygenase (Haao)^ 4.33E-04 -2.4 4.57E-05 -1.4
Isovaleryl Coenzyme A dehydrogenase (Ivd)^ 3.81E-03 -1.8   
Kynureninase (L-kynurenine hydrolase) (Kynu)^ 1.61E-02 -2.1   
Tyrosine aminotransferase (Tat)^ 1.72E-02 -2.2   
Tryptophan 2,3-dioxygenase (Tdo2)^ 3.03E-03 -1.9   
Alanyl-tRNA synthetase (Aars) 8.80E-03 -1.3   
δ-aminolevulinate synthase 2 (Alas2) 1.11E-02 -2.9   
Aldehyde dehydrogenase 4 family, member A1 (Aldh4a1) 1.28E-02 -1.4   
Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (Cad) 1.99E-02 -1.3   
Cytochrome P450, family 7, subfamily B, polypeptide 1 (Cyp7b1) 3.45E-03 -3.1   
Dopa decarboxylase (aromatic L-amino acid decarboxylase) (Ddc) 1.02E-02 -1.9   
Formiminotransferase cyclodeaminase (Ftcd) 2.88E-03 -1.6 3.52E-03 -1.3
Glycine N-methyltransferase (Gnmt) 1.05E-02 -1.5   
Sarcosine dehydrogenase, mitochondrial (Sardh)    3.73E-03 -1.2
Glucosamine-phosphate N-acetyltransferase 1 (Gnpnat1) 1.11E-02 -1.2   
Leucine aminopeptidase 3 (Lap3) 3.45E-03 -1.4 6.01E-06 -1.2
Methyltransferase like 7B (Mettl7b) 2.02E-03 -1.6   
4-hydroxyphenylpyruvate dioxygenase (Hpd)    9.17E-04 -1.3
Phenylalanine hydroxylase (Pah) 1.70E-02 -1.2 3.07E-05 -1.5
Branched-chain alpha-keto acid dehydrogenase complex component E2 (Dbt)    2.29E-03 -1.3
4-aminobutyrate aminotransferase, mitochondrial (Abat)    1.10E-03 -1.2
Urea Cycle & Metabolism of Amino Groups     
Mitochondrial ornithine transporter 1 (Slc25a15) 9.92E-03 -1.4   
Argininosuccinate synthetase 1 (Ass1)* 1.62E-02 -1.5 1.25E-07 -1.6
Argininosuccinate lyase (Asl)    1.35E-03 -1.2
Arginase 1 (Arg1)    1.53E-03 -1.2
Glutamate-ammonia ligase, Glutamine synthetase (Glul)*    1.04E-03 1.3
Carbonic anhydrase3 (C a3)    3.78E-03 -1.18
  1. *Involved in catalyzing amino acids for gluconeogenesis
  2. ^Involved in catalyzing amino acids for ketone bodies