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Table 4 Significantly Altered mRNA and Proteins related to Fatty Acid Metabolism

From: Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes

 

Transcriptomics

Proteomics

Fatty acid synthesis

Adj. p-value

Fold change

Adj. p-value

Fold change

Fatty acid synthase (Fasn)

7.80E-03

2.4

6.88E-06

1.7

Malic enzyme (Me1)

9.68E-03

2.6

3.36E-05

1.6

Acetyl-Coenzyme A carboxylase alpha (Acaca)

1.30E-03

2.6

  

Acetyl-Coenzyme A carboxylase beta (Acacb)

1.89E-02

1.8

  

Acyl-CoA synthetase medium-chain family member 5 (Acsm5)

1.94E-02

1.2

  

Acyl-CoA synthetase short-chain family member 2 (Acss2)

4.10E-03

2.5

  

Stearoyl-Coenzyme A desaturase 1 (Scd1)

7.80E-03

6.4

  

Acyl-CoA thioesterase 13 (Acot13)

1.63E-02

1.3

  

Acyl-CoA thioesterase 3 (Acot3)

1.38E-02

3.8

  

Elongation of very long chain fatty acids-like 2 (Elovl2)

7.31E-03

-1.4

  

Elongation of very long chain fatty acids -like 3 (Elovl3)

1.64E-02

-2.9

  

ELOVL family member 6, elongation of long chain fatty acids (Elovl6)

5.84E-03

2.4

  

Mitochondrial trans-2-enoyl-CoA reductase (Mecr)

1.15E-02

-1.2

  

Sterol regulatory element binding transcription factor 1 (Srebf1)

1.51E-02

1.3

  

SREBF chaperone (Scap)

3.97E-03

1.3

  

Fatty acid binding protein 5, epidermal (Fabp5)

1.01E-02

3.7

  

ATP-citrate lyase (Acly)

  

7.37E-04

1.2

Acyl-CoA binding protein (Dbi)

  

4.39E-06

1.4

Corticosteroid 11-beta-dehydrogenase isozyme 1 (Hsd11b1)

  

3.01E-03

1.4

Fatty acid ß-oxidationin mitochondria

    

Carnitine palmitoyltransferase 1a, liver (Cpt1a)

7.22E-03

-1.6

  

Carnitine palmitoyltransferase 2 (Cpt2)

2.88E-03

-1.3

  

Acyl-Coenzyme A dehydrogenase, short/branched chain (Acadsb)

9.13E-03

-1.3

  

Acetyl-CoA acyltransferase 2 (Acaa2)

  

1.13E-03

-1.3

3,2 trans-enoyl-Coenzyme A isomerase (Dci)

  

8.72E-04

-1.2

Fatty acid oxidation in peroxisome

    

3-ketoacyl-CoA thiolase B, peroxisomal (Acaa1)

  

1.99E-03

1.6

Very long-chain acyl-CoA synthetase (Slc27a2)

  

2.22E-03

1.3

Acyl-CoA oxidase 1, palmitoyl (Acox1)

  

3.96E-04

1.3

Hydroxysteroid (17-beta) dehydrogenase 4 (Hsd17b4)

  

6.40E-04

1.2

Peroxisomal bifunctional enzyme (Ehhadh)

  

8.51E-04

1.8

2-hydroxyacyl-CoA lyase 1 (Hacl1)

  

2.42E-03

1.3

Triglyceride content-related

    

Very low density lipoprotein receptor (Vldlr)

1.37E-02

3.7

  

Lipoprotein lipase (Lpl)

4.51E-03

3.3

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