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Table 4 Significantly Altered mRNA and Proteins related to Fatty Acid Metabolism

From: Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes

  Transcriptomics Proteomics
Fatty acid synthesis Adj. p-value Fold change Adj. p-value Fold change
Fatty acid synthase (Fasn) 7.80E-03 2.4 6.88E-06 1.7
Malic enzyme (Me1) 9.68E-03 2.6 3.36E-05 1.6
Acetyl-Coenzyme A carboxylase alpha (Acaca) 1.30E-03 2.6   
Acetyl-Coenzyme A carboxylase beta (Acacb) 1.89E-02 1.8   
Acyl-CoA synthetase medium-chain family member 5 (Acsm5) 1.94E-02 1.2   
Acyl-CoA synthetase short-chain family member 2 (Acss2) 4.10E-03 2.5   
Stearoyl-Coenzyme A desaturase 1 (Scd1) 7.80E-03 6.4   
Acyl-CoA thioesterase 13 (Acot13) 1.63E-02 1.3   
Acyl-CoA thioesterase 3 (Acot3) 1.38E-02 3.8   
Elongation of very long chain fatty acids-like 2 (Elovl2) 7.31E-03 -1.4   
Elongation of very long chain fatty acids -like 3 (Elovl3) 1.64E-02 -2.9   
ELOVL family member 6, elongation of long chain fatty acids (Elovl6) 5.84E-03 2.4   
Mitochondrial trans-2-enoyl-CoA reductase (Mecr) 1.15E-02 -1.2   
Sterol regulatory element binding transcription factor 1 (Srebf1) 1.51E-02 1.3   
SREBF chaperone (Scap) 3.97E-03 1.3   
Fatty acid binding protein 5, epidermal (Fabp5) 1.01E-02 3.7   
ATP-citrate lyase (Acly)    7.37E-04 1.2
Acyl-CoA binding protein (Dbi)    4.39E-06 1.4
Corticosteroid 11-beta-dehydrogenase isozyme 1 (Hsd11b1)    3.01E-03 1.4
Fatty acid ß-oxidationin mitochondria     
Carnitine palmitoyltransferase 1a, liver (Cpt1a) 7.22E-03 -1.6   
Carnitine palmitoyltransferase 2 (Cpt2) 2.88E-03 -1.3   
Acyl-Coenzyme A dehydrogenase, short/branched chain (Acadsb) 9.13E-03 -1.3   
Acetyl-CoA acyltransferase 2 (Acaa2)    1.13E-03 -1.3
3,2 trans-enoyl-Coenzyme A isomerase (Dci)    8.72E-04 -1.2
Fatty acid oxidation in peroxisome     
3-ketoacyl-CoA thiolase B, peroxisomal (Acaa1)    1.99E-03 1.6
Very long-chain acyl-CoA synthetase (Slc27a2)    2.22E-03 1.3
Acyl-CoA oxidase 1, palmitoyl (Acox1)    3.96E-04 1.3
Hydroxysteroid (17-beta) dehydrogenase 4 (Hsd17b4)    6.40E-04 1.2
Peroxisomal bifunctional enzyme (Ehhadh)    8.51E-04 1.8
2-hydroxyacyl-CoA lyase 1 (Hacl1)    2.42E-03 1.3
Triglyceride content-related     
Very low density lipoprotein receptor (Vldlr) 1.37E-02 3.7   
Lipoprotein lipase (Lpl) 4.51E-03 3.3