Table 6 Significantly Changed Plasma Metabolites (Fold of KO/WT)
Amino acids | Adj. P-value | Fold Change | Â | Adj. P-value | Fold Change |
|---|---|---|---|---|---|
Alanine | 0.00E+00 | 5.1 | Phospho-tyrosine | 1.23E-02 | -1.5 |
Arginine | 0.00E+00 | 3.9 | Glutathione Oxidized | 1.40E-03 | -2.1 |
Asparagine | 0.00E + 00 | 8.1 | Kynurenic Acid | 1.30E-03 | -2.3 |
Aspartate | 0.00E + 00 | 3.6 | S-(5'-adenosyl)-L-homocysteine | 6.40E-03 | -3.4 |
Cysteine | 0.00E + 00 | 2.7 | Nucleotides and derivatives | Â | Â |
Glutamate | 0.00E + 00 | 2.4 | Guanine | 0.00E + 00 | 2.3 |
Glutamine | 0.00E + 00 | 2.9 | Orotic Acid | 0.00E + 00 | 1.6 |
Glycine | 0.00E + 00 | 7.8 | Pyridoxine | 0.00E + 00 | 3.6 |
Histidine | 0.00E + 00 | 4 | UMP | 6.60E-03 | 2.1 |
Lysine | 0.00E + 00 | 2.9 | Uridine | 1.20E-03 | 1.7 |
Methionine | 0.00E + 00 | 1.6 | dCMP | 6.10E-03 | 2.8 |
Proline | 0.00E + 00 | 2.3 | dUTP | 1.03E-02 | -1.3 |
Serine | 0.00E + 00 | 8.7 | Bile Acids | Â | Â |
Threonine | 0.00E + 00 | 9.6 | Cholic Acid | 1.24E-02 | 244.3 |
Tyrosine | 1.00E-04 | 1.7 | Glycocholic Acid | 1.69E-02 | 154.0 |
Valine | 1.00E-04 | 1.3 | Vitamin and Cofactors | Â | Â |
Arg/urea cycle derivatives | Â | Â | Choline | 5.00E-04 | -1.3 |
a-keto-Glutarate | 0.00E + 00 | 2.3 | 5-Methyl-THF | 1.00E-04 | 3.6 |
Argininosuccinate | 7.00E-03 | 3.7 | Ascorbic Acid | 7.70E-03 | -1.2 |
Citrulline | 0.00E + 00 | 3.3 | Biotin | 1.95E-02 | 1.6 |
L-NMMA | 0.00E + 00 | 4.3 | Dihydrofolic Acid | 0.00E + 00 | 5.3 |
Ornithine | 0.00E + 00 | 5.4 | Pantothenic Acid | 0.00E + 00 | 1.7 |
SDMA | 5.00E-04 | 1.7 | Pyridoxal-5-phosphate | 1.64E-02 | 1.5 |
Met/Cys derivatives | Â | Â | 4-Pyridoxic_Acid | 2.00E-04 | 2.0 |
Cystathionie | 0.00E + 00 | 3.7 | Betaine | 0.00E + 00 | 2.8 |
Homocysteine | 0.00E + 00 | 2.4 | Glycerol and derivatives | Â | Â |
Other AA derivatives | Â | Â | Glycerate-3-P | 5.00E-04 | -2.2 |
2-Aminodipic Acid | 0.00E + 00 | 5.4 | Glyceraldehyde | 6.40E-03 | -1.3 |
Dimethyl Glycine | 0.00E + 00 | 3.1 | Glycerate-2-P | 1.00E-04 | -2.3 |
Homoserine | 2.60E-03 | 3 | Glycerol | 0.00E + 00 | -2.7 |
Hydroxyproline | 1.40E-03 | 2.7 | Phosphoenolpyruvate | 2.00E-04 | -2.3 |
L-5-Hydroxytryptophan | 4.00E-04 | 2.2 | Carbohydrates | Â | Â |
Creatine | 0.00E + 00 | 2 | Glucose | 1.00E-04 | -1.4 |
N-Carbamyl-b-Alanine | 1.80E-03 | 1.7 | Fructose | 1.80E-03 | -1.4 |
Trimethylamine-N-Oxide | 1.90E-03 | 1.7 | Lactose | 0.00E + 00 | -2.0 |
GABA | 1.81E-02 | 1.5 | UDP-Glucose | 5.20E-03 | -1.9 |