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Table 6 Significantly Changed Plasma Metabolites (Fold of KO/WT)

From: Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes

Amino acids Adj. P-value Fold Change   Adj. P-value Fold Change
Alanine 0.00E+00 5.1 Phospho-tyrosine 1.23E-02 -1.5
Arginine 0.00E+00 3.9 Glutathione Oxidized 1.40E-03 -2.1
Asparagine 0.00E + 00 8.1 Kynurenic Acid 1.30E-03 -2.3
Aspartate 0.00E + 00 3.6 S-(5'-adenosyl)-L-homocysteine 6.40E-03 -3.4
Cysteine 0.00E + 00 2.7 Nucleotides and derivatives   
Glutamate 0.00E + 00 2.4 Guanine 0.00E + 00 2.3
Glutamine 0.00E + 00 2.9 Orotic Acid 0.00E + 00 1.6
Glycine 0.00E + 00 7.8 Pyridoxine 0.00E + 00 3.6
Histidine 0.00E + 00 4 UMP 6.60E-03 2.1
Lysine 0.00E + 00 2.9 Uridine 1.20E-03 1.7
Methionine 0.00E + 00 1.6 dCMP 6.10E-03 2.8
Proline 0.00E + 00 2.3 dUTP 1.03E-02 -1.3
Serine 0.00E + 00 8.7 Bile Acids   
Threonine 0.00E + 00 9.6 Cholic Acid 1.24E-02 244.3
Tyrosine 1.00E-04 1.7 Glycocholic Acid 1.69E-02 154.0
Valine 1.00E-04 1.3 Vitamin and Cofactors   
Arg/urea cycle derivatives    Choline 5.00E-04 -1.3
a-keto-Glutarate 0.00E + 00 2.3 5-Methyl-THF 1.00E-04 3.6
Argininosuccinate 7.00E-03 3.7 Ascorbic Acid 7.70E-03 -1.2
Citrulline 0.00E + 00 3.3 Biotin 1.95E-02 1.6
L-NMMA 0.00E + 00 4.3 Dihydrofolic Acid 0.00E + 00 5.3
Ornithine 0.00E + 00 5.4 Pantothenic Acid 0.00E + 00 1.7
SDMA 5.00E-04 1.7 Pyridoxal-5-phosphate 1.64E-02 1.5
Met/Cys derivatives    4-Pyridoxic_Acid 2.00E-04 2.0
Cystathionie 0.00E + 00 3.7 Betaine 0.00E + 00 2.8
Homocysteine 0.00E + 00 2.4 Glycerol and derivatives   
Other AA derivatives    Glycerate-3-P 5.00E-04 -2.2
2-Aminodipic Acid 0.00E + 00 5.4 Glyceraldehyde 6.40E-03 -1.3
Dimethyl Glycine 0.00E + 00 3.1 Glycerate-2-P 1.00E-04 -2.3
Homoserine 2.60E-03 3 Glycerol 0.00E + 00 -2.7
Hydroxyproline 1.40E-03 2.7 Phosphoenolpyruvate 2.00E-04 -2.3
L-5-Hydroxytryptophan 4.00E-04 2.2 Carbohydrates   
Creatine 0.00E + 00 2 Glucose 1.00E-04 -1.4
N-Carbamyl-b-Alanine 1.80E-03 1.7 Fructose 1.80E-03 -1.4
Trimethylamine-N-Oxide 1.90E-03 1.7 Lactose 0.00E + 00 -2.0
GABA 1.81E-02 1.5 UDP-Glucose 5.20E-03 -1.9