Figure 3
Phylogeny of the phage-encoded peptidoglycan hydrolase, N-acetylmuramoyl-L-alanine amidase. Sequences represent 31 phage sequences available from IMG retrieved based on annotations of COG0860 or PF01520. Sequences were aligned to a hidden Markov-model based on representative sequences from cd02696 of the CDD as described fully in the text. Domain architecture is shown by symbols on outer ringfor genes immediately upstream and downstream of the endolysin. Gene symbols are scaled according to gene lengths and coordinates as published for each genome. Clade shading scheme represents phage host as shown in the legend; significant associations between phage host and gene phylogeny were determined by UniFrac statistics based on branch length (p < 0.001) and P-tests based on topology (p < 0.001).