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Figure 2 | BMC Genomics

Figure 2

From: Gene expression profiling of rat spermatogonia and Sertoli cells reveals signaling pathways from stem cells to niche and testicular cancer cells to surrounding stroma

Figure 2

Expression profiles of Spga and Sertoli cells from pre-pubertal and pubertal rats. (A) Triplicate profiles of the 6908 genes which were differentially expressed in the 4 types of cells (germ cells at 9 dpp and 22 dpp {G9 and G22 respectively} and Sertoli cells at 9 dpp and 22 dpp respectively) were hierarchically clustered and are presented as a heat-map. Hierarchy and deviance are shown on top of the heat-map. Expression level of each transcript is indicated in the color code bar, red for high and green for low expression. (B) Venn diagrams showing genes which are at least twofold over-expressed in pair wise comparison of mean expression levels between either the same cell type (e.g. G9 vs G22) or the same developmental stage (e.g. G9 vs. S9). Overlap defines 4 "selective" gene sets: G9-sel (red); S9-sel (green); G22-sel (blue); S22-sel (orange). Genes of these 4 sets are marked by small colored bars on the right of the heat-map in panel A. (C) Hierarchical re-clustering of the 4 "selective" gene sets. Gene tree clustering parameters: Pearson Correlation, average linkage algorithm.

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