Figure 5

Orthology Relationships. (A) The oldest common ancestor in gene-families to either a Dipteran, Coleopteran, Hymenopteran or Metazoan ancestor. (B) Expression divergence of tissues for one-to-one orthology pairs (n = 4234). Euclidean distance was used to calculate similarity among tissues within and between species. Branch support was estimated with 10,000 bootstrapped replicates. Drosophila (grey); Anopheles (black). (C) Mean expression of Anopheles orthologue clusters and (D) mean expression of Drosophila orthologues clusters. Mean relative expression (RA) level for each cluster according to grayscale. (E) The number of overlapping orthologous genes between Anopheles and Drosophila expression clusters calculated with a hypergeometric probability distribution after multiple correction. Light grey (P < 0.05); Dark grey (P < 0.01).