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Table 2 Comparison of DNA methylation levels with gene expression levels.

From: Comprehensive profiling of zebrafish hepatic proximal promoter CpG island methylation and its modification during chemical carcinogenesis

Gene name

Symbol

Chr. no

Expression level

Methylation level

Gene ID

Matrix metalloproteinase 14 (membrane-inserted) alpha

mmp14a

7

↑

↓

ENSDARG00000002235

Histidyl-tRNA synthetase

hars

14

↑

↓

ENSDARG00000003693

Tubulin, alpha 8 like 4

tuba8l4

6

↑

↓

ENSDARG00000006260

E2F transcription factor 6

e2f6

20

↓

↓

ENSDARG00000008119

Acetoacetyl-CoA synthetase

aacs

5

↑

↑

ENSDARG00000012468

Nucleophosmin 1

npm1

10

↑

↓

ENSDARG00000014329

Cell division protein kinase 8 (probe 54)

cdk8

24

↑

↓

ENSDARG00000016496

Cell division protein kinase 8 (probes 21, 31)

cdk8

24

↑

↑

ENSDARG00000016496

Hepatoma-derived growth factor-related protein 2

hdgfrp2

22

↑

↓

ENSDARG00000019530

RAB2A, member RAS oncogene family

rab2

2

↑

↓

ENSDARG00000020261

LIM domain containing preferred translocation partner in lipoma

lpp

6

↑

↓

ENSDARG00000023578

Insulin-like growth factor binding protein 5a

igfbp5b

9

↓

↓

ENSDARG00000025348

Mitogen-activated protein kinase 1

mapk1

5

↑

↓

ENSDARG00000027552

Cancer susceptibility candidate gene 3 protein homolog

casc3

3

↑

↑

ENSDARG00000029911

Hnrpa0l protein

hnrpa0l

14

↑

↓

ENSDARG00000036161

Cyclin T2

ccnt2

9

↑

↓

ENSDARG00000036685

Proliferating cell nuclear antigen

pcna

10

↑

↓

ENSDARG00000054155

Ret proto-oncogene (probes 16, 19)

ret

13

↓

↑

ENSDARG00000055305

Ret proto-oncogene (probes 20, 24)

ret

13

↓

↓

ENSDARG00000055305

Integrin-linked kinase (probes 8, 1)

ilk

10

↑

↓

ENSDARG00000056964

Integrin-linked kinase (probes 6)

ilk

10

↑

↑

ENSDARG00000056964

Novel protein similar to vertebrate threonyl-tRNA synthetase

tars

18

↑

↑

ENSDARG00000075429

Ribonuclease inhibitor 1

rnh1

22

↓

↓

ENSDARG00000078234

Calpain 2, (m/II) large subunit, like

capn2

22

↑

↓

ENSDARG00000034211

Synaptopodin-2

synp02

7

↓

↑

ENSDARG00000079675

  1. Genes with both significantly altered gene expression levels and DNA methylation levels (> 1.5 fold) (expression level: ↑ up regulated, ↓ down regulated; methylation level: ↑ hypermethylated, ↓ hypomethylated).