Figure 5

Interactions between refined PB motifs and PDZ proteins. (a) Comparison of the C-terminal sequences of mInsc and voltage-dependent sodium channel Nav1.4. (b) Comparison of the C-terminal sequences of DTWD2 and GluR2. AA identified in Figure 4 at each position are indicated with diffent colors (-4: green, -3: red, -1: yellow). (c) Bindings between mInsc and PSD-95 in physiological conditions, which is dependent on the PB motif of mInsc. (d) Bindings between DTWD2 and GRIP1 mediated by PB motif of DTWD2. (e) PB motifs of NS1 proteins of several Influenza strains. C-terminal thirty AA sequences of NS1 proteins are shown. Upper strain (A/Brevig Mission/1/1918(H1N1)) caused Spanish Flu in 1918 and middle (A/Hong Kong/213/2003(H5N1)) caused outbreaks of avian influenza among humans in 2003-2004. The lower (A/New York/1/2003(H3N2)) is shown as a representative example of a strain that causes seasonal flu widely and predominantly spreads among humans. AAs identified in Figure 4 are also indicated with different colors (positions - 4, -3 and -1 are indicated in green, red and yellow, respectively).