Table 2 Diseases associated with genes containing nsSNPs
From: Characterization of single-nucleotide variation in Indian-origin rhesus macaques (Macaca mulatta)
General Category | # Associated Deleterious SNPs | Gene names | Diseases | ||
|---|---|---|---|---|---|
Apoptosis | 8 | CYCS; | Huntington's disease | DNA damage | Alzheimer's disease |
TNFRSF10D; | Thrombocytopenia | Bipolar | Rheumatoid arthritis | ||
CASP7; MAP3K1; | Diabetes mellitus type I | Renal cell carcinoma | Myeloproliferative disorders | ||
PRKCZ; MPL; | |||||
TNFRSF19 | Leukemia | Diabetes mellitus type II | Amyotrophic lateral Sclerosis | ||
Pancreatitis | Carcinoma (multiple types) | Multiple sclerosis | |||
Cell cycle | 20 | BRCA2; POLD2; | Spontaneous abortion | Genomic instability | Drug toxicity |
CDC14A; CDT1; | |||||
CHAF1A; WRN; | Endometriosis | Anemia | Li-Fraumeni Syndrome | ||
IPO5; KIF23; TTK; | Aneuploidy | Amyotrophic lateral Sclerosis | Diabetes mellitus type I | ||
MSH2; CASC5; | |||||
PRKCZ; CASP7; | Carcinoma (multiple types) | Diabetes mellitus type II | Werner Syndrome | ||
SERPINB13; | |||||
LATS1 | Male infertility | Rheumatoid arthritis | osteoporosis | ||
Development | 11 | NCOA6; PABPN1; | Carcinoma (multiple types) | Endometriosis | Asthma |
LTF; MAP3K1; | |||||
TLL1; YAP1; SPEN; | Deglutition disorders | Male infertility | Coronary disease | ||
IL18R1 | Oculopharyngeal Muscular dystrophy | Li-Fraumeni Syndrome | Idiopathic pulmonary fibrosis | ||
DNA repair | 9 | BRCA2; CHAF1A; | Genomic instability | Werner Syndrome | Fanconi anemia |
FANCM; RAD51L1; | Carcinoma (multiple types) | Diabetes mellitus type I | Drug toxicity | ||
WRN; MSH2 | |||||
Inflammation | 22 | CYCS; SOCS6; | Huntington's disease | Severe combined Immunodeficiency | Stomach ulcer |
BDKRB1; HPRT1; | |||||
IL18R1; IL7R; | Thrombocytopenia | Multiple sclerosis | Ataxia | ||
MAP3K1; 1L27RA; | Asthma | Rheumatoid arthritis | Leukemia | ||
PRKCZ; OAS2; | Diabetes mellitus type I | Myeloproliferative disorders | Sarcoidosis | ||
CD53; LAMA3; | |||||
LAMA4; IL174A; | Diabetic nephropathies | Crohn's disease | Carcinoma (multiple types) | ||
HABP2; KLKB1 | |||||
Autosomal dominant polycystic kidney | Sjogren's syndrome | Gout | |||
Rhinitis | Nasal polyps | Telangiectasis | |||
Lesch-Nyhan syndrome | Arteriosclerosis | Genome instability | |||
Metabolism | 4 | P2RX2; LTF; | Anoxia | Encephalitis | Rheumatoid arthritis |
ACACB; PRKCZ | Carcinoma (multiple types) | Diabetes mellitus type II | Glomberulonephritis | ||
Nervous System | 17 | CDK5RAP2; | Microcephaly | Lipodystrophy | Rheumatoid arthritis |
P2RX2; | Anoxia | Mucolipidoses | Fragile X Syndrome | ||
ST8S1A2; HTR1F; | Schizophrenia | Pain | Liver cirrhosis | ||
SCN10A; SLC28A2; | Parkinson's disease | Asthma | Diabetes mellitus type I | ||
MCOLN1; DLGAP4; | Glioma | Acquired immunodeficiency | |||
SYT8; ATP2B3; | |||||
MAP1A; LAMA4; | |||||
MAP3K1; AHNAK; | |||||
AFF2; CASP7 | |||||
Protein folding | 4 | CHAF1A; GRPEL1; | Aneurysm | Pulmonary fibrosis | Diabetes mellitus type I |
HSPA4; EEF1A2; | |||||
Carcinoma (multiple types) | Graft vs. host disease | Paralysis | |||
Reproduction | 13 | SPDY1; CENPI; | Gastrointestinal diseases | Hyperaldosteronism | Genomic instability |
BRCA2; NCOA4; | |||||
RBAK; CASC5; | Carcinoma (multiple types) | Diabetes mellitus type II | Oligospermia | ||
PRKCZ; MAP3K1 | |||||
anemia | |||||
Signal transduction | 19 | BRCA2; CASP7; | Spontaneous abortion | Arteriosclerosis | Dilated cardiomyopathy |
NCOA6;IL7R; | |||||
CYCS; BAMBI; | Carcinoma (multiple types) | Hypertension | Asthma | ||
KLKB1; IL17RA; | |||||
MAP3K1; DSG2; | Huntington's disease | Severe combined immunodeficiency | Sarcoidosis | ||
PRKCZ; IFI44; | |||||
IL18R1; HABP2; | Thrombocytopenia | Multiple sclerosis | Diabetes mellitus type I | ||
Rheumatoid arthritis | Alzheimer's disease | Arrhythmogenic right ventricular dysplasia | |||
Transcription | 8 | NCOA6; BRCA2; | Retinoblastoma | Oculopharyngeal muscular dystrophies | Rheumatoid arthritis |
MAP3K1; TAF3; | |||||
PABPN1 | Spontaneous abortion | Aneuploidy | Deglutition disorders | ||
Carcinoma (multiple types) | Infertility | ||||
Transport | 11 | KCNH3; LTF; | Anemia | Genomic instability | Liver cirrhosis |
MSH2;NCOA4; | Alzheimer's disease | Crohn's disease | Obesity | ||
PPARGC1B; | Epilepsy | Diabetes mellitus type II | Barrett esophagus | ||
ZNF217; | Carcinoma (multiple types) | Gastritis | progeria | ||
ME2;P2RX2;ANK3; | |||||
LATS1; MAT2A | |||||