Figure 6

Significant pathways and interactions among EGF-regulated geneset. (A) Core functional analysis of EGF-regulated genes derived from the RankProd test clustering around canonical pathways performed using the Ingenuity Pathway Analysis software. (B) Pathway analysis based on the Ingenuity Pathway Knowledge base. The two best ranked networks holding EGF-regulated genes derived from the RankProd test were merged showing a unique network. Up-regulated genes are indicated in red and down-regulated genes in green. The shape of the node denotes the main function of the protein encoded by the gene (see boxed inset). Continuous lines indicate interaction between the products of the genes; dashed lines indicate an indirect interaction; lines with an arrow indicate that the source gene "acts on" the target gene. Regulated genes are shown as grey boxes and non-regulated but associated with the regulation of some of these genes are shown as white nodes. Orange lines indicate new gene relationships appearing after merging different networks.