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Figure 5 | BMC Genomics

Figure 5

From: Evolutionary conserved microRNAs are ubiquitously expressed compared to tick-specific miRNAs in the cattle tick Rhipicephalus (Boophilus) microplus

Figure 5

Evolutionary conservation of R. microplus miRNAs. A) R. microplus phylogentic relationships highlighting relevant ancestors are shown. The tree topology was modified from [21]. Diverge times were taken from [16] and [21]; Nephrozoan anecestor = 641-686 MYA; Protostomian ancestor = 618-653 MYA; Arthropoda ancestor = 540MYA. B) Percentage fraction and R. microplus miRNAs perfectly conserved since various ancestors are shown as well as those miRNAs representing unique R. microplus sequence variants. C) The average number of nucleotide substitutions in miRNAs is shown for the various subsets shown in panel B. MiRNA variants that are unique to R. microplus were further divided into three groups as described in the text. Only miRNA for which an ancestral sequence was available were considered, except for Rmi-III where nucleotide changes were compared against known orthologs in insecta species (Additional file 13).

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