Figure 5
(A) Degree to which conserved TFBSs in promoter regions of miRNAs up-regulated in DCs are shared among their promoters. (B) The distribution of the number of common TFBS hits per number of common miRNA promoters as in A, for test and random sets of miRNA promoters. (A) Degree to which conserved TFBSs in promoter regions of miRNAs up-regulated in DCs are shared among their promoters. Shown on the x-axis are high-scoring TFBSs filtered at a motif instance score threshold of at least 6 and at a 10th percentile evolutionary conservation score that occur at least once in the promoters of miRNAs up-regulated in DCs. The y-axis shows the number of promoters that have the TFBS at least once at these thresholds. (B) The distribution of the number of common TFBS hits per number of common miRNA promoters as in A, for test and random sets of miRNA promoters. The values for random are the median values from 1000 random sets of miRNA promoters of the same size and length as those in the DC set. The score is the ratio of the sum of all occurrences of conserved TFBS for the DC set relative to that of the random sets. The p-value is estimated from the number of instances wherein this sum for 1000 random sets of miRNA promoters is greater than or equal to that of the DC set.