Table 1 Biological processes significantly affected (p < 0.05) and over-represented after BaP treatment in synchronised MCF-7 cells in G0/G1, S, and G2/M as determined by Gene Ontology (GO) analysis within GeneSpring software
From: Influence of cell cycle on responses of MCF-7 cells to benzo[a]pyrene
Biological Process | % of Genes in List | p-Value |
|---|---|---|
G1 -enriched cells | ||
GO:7275: development | 26.4 | 1.50E-03 |
GO:9653: morphogenesis | 11.8 | 1.60E-02 |
GO:30154: cell differentiation | 11.4 | 1.20E-02 |
GO:9059: macromolecule biosynthesis | 10 | 1.10E-02 |
GO:8283: cell proliferation | 8.6 | 1.90E-02 |
GO:31325: positive regulation of cellular metabolism | 5 | 3.10E-02 |
GO:45941: positive regulation of transcription | 4.1 | 4.90E-02 |
GO:45321: immune cell activation | 3.2 | 2.30E-02 |
GO:51606: detection of stimulus | 2.3 | 4.00E-03 |
S -enriched cells | ||
GO:50789: regulation of biological process | 42.7 | 1.30E-02 |
GO:42127: regulation of cell proliferation | 7.3 | 2.10E-02 |
GO:40007: growth | 5.5 | 1.70E-02 |
GO:42592: homeostasis | 5.5 | 4.10E-02 |
GO:45944: positive regulation of transcription from RNA polymerase II promoter | 3.6 | 2.20E-02 |
GO:7420: brain development | 2.7 | 4.60E-02 |
GO:9065: glutamine family amino acid catabolism | 1.8 | 7.20E-03 |
GO:6805: xenobiotic metabolism | 1.8 | 2.10E-02 |
GO:9266: response to temperature stimulus | 1.8 | 2.10E-02 |
GO:7157: heterophilic cell adhesion | 1.8 | 2.20E-02 |
GO:6664: glycolipid metabolism | 1.8 | 2.70E-02 |
GO:30203: glycosaminoglycan metabolism | 1.8 | 5.00E-02 |
GO:35026: leading edge cell differentiation | 0.9 | 5.60E-03 |
GO:42268: regulation of cytolysis | 0.9 | 5.60E-03 |
GO:46399: glucuronate biosynthesis | 0.9 | 1.10E-02 |
GO:16264: gap junction assembly | 0.9 | 1.70E-02 |
GO:6975: DNA damage induced protein phosphorylation | 0.9 | 1.70E-02 |
GO:48246: macrophage chemotaxis | 0.9 | 3.30E-02 |
G2/M -enriched cells | ||
GO:19219: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism | 23.9 | 1.40E-03 |
GO:6355: regulation of transcription, DNA-dependent | 21.8 | 1.80E-02 |
GO:30154: cell differentiation | 10.6 | 1.10E-02 |
GO:7049: cell cycle | 9.9 | 2.70E-04 |
GO:7264: small GTPase mediated signal transduction | 6.3 | 6.90E-03 |
GO:9888: tissue development | 4.2 | 1.30E-02 |
GO:16337: cell-cell adhesion | 3.5 | 6.20E-03 |
GO:165: MAPKKK cascade | 2.8 | 1.70E-02 |
GO:31098: stress-activated protein kinase signaling pathway | 1.8 | 2.30E-03 |
GO:8624: induction of apoptosis by extracellular signals | 1.4 | 3.70E-02 |
GO:42551: neuron maturation | 1.4 | 3.00E-03 |
GO:6986: response to unfolded protein | 1.4 | 1.10E-02 |
GO:51259: protein oligomerization | 1.4 | 2.60E-02 |
GO:9266: response to temperature stimulus | 1.1 | 1.50E-02 |