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Table 2 Summary of selected transcripts expressed after challenges with PGN-K12.

From: Divergent responses to peptidoglycans derived from different E. coli serotypes influence inflammatory outcome in trout, Oncorhynchus mykiss, macrophages

 

Early

Median

Late

Antigen presenttion

Mean

SD

Mean

SD

Mean

SD

MHC class I heavy chain-1

1.6

0.3

3.8

1.1

4.1

3.9

BPI binding protein

3.4

2.5

n/s

n/s

1.5

0.6

Macrophage receptor MARCO

n/s

n/s

n/s

n/s

0.4

1.8

Cell adhesion and proliferation

      

Fibronectin receptor beta

11.6

11.3

n/s

n/s

n/s

n/s

CD2 binding protein 1-1

2.9

1.1

n/s

n/s

n/s

n/s

Matrix metalloproteinase 9

2.0

0.7

n/s

n/s

-4.7

1.8

Cytokines and Chemokines

      

Cytokine receptor gamma chain

1.7

0.5

n/s

n/s

n/s

n/s

CC chemokine SCYA110-1

n/s

n/s

n/s

n/s

1.2

0.1

Cellullar defense response

      

TNF receptor associated factor 1

n/s

n/s

4.6

4.1

n/s

n/s

NF-kappaB inhibitor alpha-1

4.6

4.3

n/s

n/s

n/s

n/s

Cathepsin C-3

2.8

2.3

n/s

n/s

n/s

n/s

Cathepsin D-1

3.2

2.8

n/s

n/s

1.6

0.5

Cathepsin D-2

3.7

3.6

n/s

n/s

n/s

n/s

MAPK/ERK

      

MAPK/ERK kinase kinase 6

1.7

0.3

2.1

0.5

n/s

n/s

Serine/threonine-protein kinase 2

2.9

2.2

n/s

n/s

-1.2

0.1

Tyrosine-protein kinase FRK

n/s

n/s

n/s

n/s

1.7

0.5

Tyrosine-protein kinase SYK

n/s

n/s

n/s

n/s

-2.0

1.4

Inflammatory response

      

Annexin A1-1

9.8

9.4

n/s

n/s

1.4

0.3

Microsomal glutathione S-transferase 3

-1.6

0.2

-1.4

0.2

1.2

0.1

Arachidonate 5-lipoxygenase-1

-3.4

0.4

n/s

n/s

n/s

n/s

Prostaglandine D synthase

1.3

0.1

n/s

n/s

n/s

n/s

Angiotensin I converting enzyme

0.0

n/s

n/s

n/s

1.2

n/s

Cell homeostasis

      

Metallothionein A

-4.4

1.1

n/s

n/s

1.4

0.2

Heat shock 27 kDa protein-1

2.8

0.8

n/s

n/s

-1.8

0.6

Heat shock 70 kDa protein 1

3.0

1.4

n/s

n/s

-1.7

0.4

Glutathione reductase

2.0

0.8

n/s

n/s

-2.2

1.0

Cellular metabolism

      

Malate dehydrogenase, cytoplasmic

2.1

0.6

n/s

n/s

n/s

n/s

Glucose-6-phosphate isomerase-1

n/s

n/s

n/s

n/s

2.4

1.7

ATP synthase factor 6

2.4

1.7

n/s

n/s

n/s

n/s

Transcription

      

Reverse transcriptase-like-2

2.4

1.7

-2.7

0.6

n/s

n/s

CCAAT/enhancer binding protein beta

n/s

n/s

7.0

2.6

1.4

0.5

Chromatin dis-assembly

      

Transposase-15

-4.0

3.4

n/s

n/s

-1.3

0.3

Transposase-56

n/s

n/s

-3.4

0.5

n/s

n/s

G1/S-specific cyclin D2

-3.1

2.0

-3.6

1.4

1.5

0.4

  1. Transcripts represented were selected for expression level (p < 0.01) and then implication in biological processes related to PGN stimulation (immune/inflammatory responses) during PGN-K12. n/s: no signal. Mean: Fold expression average (n = 3), SD: standard deviation.
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BMC Genomics

ISSN: 1471-2164

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