Leaderless genes in bacteria: clue to the evolution of translation initiation mechanisms in prokaryotes

BMC Genomics

Table 1 Documented leaderless genes in S. coelicolor A3(2)

Gene name	Sequence upstream of TIS¹	Probability²	Ref.
absA	CGCTCTTG TAGCGT GC TGGAA TG	0.95	[52]
devA	CGAAGTTGTAGCGTTT GGTCG TG	0.93	[53]
fabD	CCTCAAGAGAGAGTGT GAGAG TG	0.51	[54]
furA	CAGGGAG TAGGTT CG CCGCCA TG	0.80	[55]
KbpA	GACGCGGT TACTTT GA CGGCA TG	0.93	[56]
malR	GACAGG TACAGT CC ACCCCTG TG	0.63	[57]
phoRP	GCCGTGCC TAACCT GG AGACA TG	0.91	[58]
vanH	GAGGCGCCTTGAATAG AGGCA TG	0.27	[59]
vanK	CCGCCGCCTTGACTGG GGGCA TG	0.78	[59]
vanR	CGACTCGTAATCTCG ACACCA TG	0.85	[59]
ptsH	CACCTGAAGGGCAGCAT CACATG	0.00	[20]
sigJ	GCCTCGGGTAG AAAATCCACA TG	0.03	[21]
whiH	TCGGCGCCGACAA AGGATGC GTG	0.09	[19]

¹The last three characters are triplet for start codons, experimentally determined TSSs are bold, and the most-likely Pribnow boxs are italic. The -10 promoters proposed in literature, if available, are underlined.
²The probability that a gene is a leaderless gene regulated by σ⁷⁰ was calculated by Eq. 5.

ISSN: 1471-2164