Figure 1

Summary of AhR enrichment within Cyp1a1 genic region at 2 and 24 hrs. Cyp1a1 is represented by two RefSeq sequences (NM_009992 and NM_001136059, dark blue tracks) that have different TSSs (dark blue box at far left). The rectangles and lines represent exons and introns, respectively, and the UTRs are depicted as the thinner rectangles. Arrowhead direction indicates the orientation of the gene. The grey boxes above represent the Affymetrix 2.0R mouse tiling array probe locations across the Cyp1a1 genic regions. The location and matrix similarity (MS) scores of the consensus DREs are represented by the purple histogram. The highlighted yellow box identifies bona fide functional DREs (matrix similarity (MS) score ≥ 0.8473) involved in AhR-mediated Cyp1a1 gene expression. The red boxes identify regions of significant AhR enrichments (FDR < 0.01) based on the moving average (MA) profile by TileMap. The green histogram plots the log₂ fold enrichment values for each individual probe.