Circos plots integrating DRE analysis, AhR enrichment (2 hrs; FDR < 0.01) and heatmaps for hepatic differential gene expression responses (|fold change| ≥ 1.5 and P1(t) > 0.999) induced by TCDD across the genome (A) and chromosome 9 (B). The inset legend image provides information represented by each data ring. DRE matrix similarity (MS) scores and AhR enrichment values increase radially outward. The time points for the gene expression heatmaps also increase radial outward. The arc of each heatmap wedge maps directly to the location of the gene in the genome. The arc length is proportional to the length of the transcribed region. Circos plots for the other chromosomes are provided in Additional File 12.