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Table 3 Significantly over-represent transcription factor module families in TCDD-induced AhR enriched regionsa.

From: Integration of Genome-Wide Computation DRE Search, AhR ChIP-chip and Gene Expression Analyses of TCDD-Elicited Responses in the Mouse Liver

TF Module Family Module Description 2 hr AhR enriched regions 24 hr AhR enriched regions
   # of matches Expected # of matches Over-representaionb Z-Score # of matches Expected # of matches Over-representaionb Z-Score
AHR AhR-ARNT heterodimer 9,447 4,278.30 2.21 79.03 851 297.44 2.86 32.07
SP1 GC-Box factors SP1/GC 19,356 12,839.04 1.51 57.54 1,346 892.61 1.51 15.17
HIF Hypoxia inducible factor, bHLH/PAS protein family 8,763 4,841.13 1.81 56.37 569 336.57 1.69 12.64
E2F E2F-Myc activator/cell cycle regulator 18,247 12,444.88 1.47 52.04 1,266 865.21 1.46 13.62
ZBP Zinc binding protein factors 25,542 18,518.20 1.38 51.65 1,739 1,287.45 1.35 12.58
NRF1 Nuclear respiratory factor 1 3.475 1,494.81 2.32 51.21 252 103.92 2.42 14.48
ZF5 ZF5 POZ domain zinc finger 3,156 1,442.92 2.19 45.09 205 100.32 2.04 10.40
NF1 Nuclear factor 1 13,047 8,876.90 1.47 44.27 886 617.15 1.44 10.81
NR2F Nuclear receptor subfamily 2 factors 44,774 36,390.64 1.23 44.02 3,180 2,530.00 1.26 12.93
EGR EGR/nerve growth factor included protein c 22,224 16,794.62 1.32 41.92 1,541 1,167.62 1.32 11.
PPAR Peroxisome proliferator-activated receptor 24,808 19,035.70 1.30 41.87 1,752 1,323.43 1.32 11.78
RXR RXR heterodimer binding sites 41,027 33,441.00 1.23 41.54 2,932 2,324.93 1.26 12.60
WHN Winged helix binding sites 3,030 1,477.23 2.05 40.39 206 102.70 2.01 10.14
  1. a AhR enriched regions with a FDR < 0.01
  2. b total number of matches in enriched regions/expected number of matches in genome
  3. Complete list of over-represented TF module families are provided in Additional Files 6 and 7