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Table 4 Distribution and AhR enrichment and DRE analysis of differentially expressed genes elicited by TCDD.

From: Integration of Genome-Wide Computation DRE Search, AhR ChIP-chip and Gene Expression Analyses of TCDD-Elicited Responses in the Mouse Liver

    2 hr 4 hr 8 hr 12 hr 18 hr 24 hr 72 hr 168 hr
Number of differentially expressed genes a Up-regulated Total 68 255 341 218 236 287 267 719
   With AhR enrichmentb 55 200 202 148 172 186 164 243
   With AhR enrichmentb + DRE corec 47 168 171 126 146 156 135 181
  Down-regulated Total 18 233 116 168 105 237 261 218
   With AhR enrichmentb 10 123 76 102 59 131 137 123
   With AhR enrichmentb + DRE corec 6 79 49 63 30 72 79 70
  1. a |fold-change| ≥ 1.5 and P1(t) > 0.999
  2. b AhR enriched regions at 2 hrs with FDR < 0.01
  3. c 5'-GCGTG-3' core sequence within AhR enriched region
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BMC Genomics

ISSN: 1471-2164

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