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Table 5 Functional enrichment analysis of differently regulateda genes with AhR enrichmentb using DAVID.

From: Integration of Genome-Wide Computation DRE Search, AhR ChIP-chip and Gene Expression Analyses of TCDD-Elicited Responses in the Mouse Liver

Category

Team

Gene Count

Fold enrichment

P-value

Enrichment Score: 7.34

   GOTERM_BP_3

GO:0006629 ~ lipid metabolic process

76

2.23

5.53E-11

   GOTERM_BP_3

GO:0044255 ~ cellular lipid metabolic process

53

2.23

7.80E-08

   GOTERM_BP_3

GO:0008610 ~ lipid biosynthetic process

32

2.30

2.28E-05

Enrichment Score:4.12

   GOTERM_BP_3

GO:0048523 ~ negative regulation of cellular process

94

1.60

4.46E-06

   GOTERM_BP_3

GO:0048519 ~ negative regulation of biological process

101

1.54

7.83E-06

   GOTERM_BP_3

GO:0031324 ~ negative regulation of cellular metabolic process

45

1.85

8.99E-05

   GOTERM_BP_3

GO:0051172 ~ negative regulation of nitrogen compound metabolic process

39

1.96

9.68E-05

   GOTERM_BP_3

GO:0009890 ~ negative regulation of biosynthetic process

40

1.86

2.33E-04

   GOTERM_BP_3

GO:0009892 ~ negative regulation of metabolic process

46

1.74

3.20E-04

   GOTERM_BP_3

GO:0010605 ~ negative regulation of macromolecule metabolic process

43

1.72

6.88E-04

Enrichment Score: 3.54

   GOTERM_BP_3

GO:0009410 ~ response to xenobiotic stimulus

8

10.59

3.54E-06

   GOTERM_BP_3

GO:0006805 ~ xenobiotic metabolic process

7

11.59

1.12E-05

   GOTERM_BP_3

GO:0018894 ~ dibenzo-p-dioxin metabolic process

3

19.86

7.31E-03

   GOTERM_BP_3

GO:0009404 ~ toxin metabolic process

3

11.92

2.28E-02

Enrichment Score: 2.70

   GOTERM_BP_3

GO:0051272 ~ positive regulation of call motion

9

4.58

6.00E-04

   GOTERM_BP_3

GO:0051270 ~ regulation of cell motion

15

2.84

7.55E-04

   GOTERM_BP_3

GO:0040017 ~ Positive regulation of locomotion

9

4.26

1.01E-03

   GOTERM_BP_3

GO:0030334 ~ regulation of cell migration

13

2.87

1.76E-03

   GOTERM_BP_3

GO:0040012 ~ regulation of locomotion

13

2.39

7.93E-03

   GOTERM_BP_3

GO:0040012 ~ regulation of localization

32

1.61

9.36E-03

Enrichment Score: 2.55

   GOTERM_BP_3

GO:0048518 ~ positive regulation of biological process

106

1.44

7.45E-05

   GOTERM_BP_3

GO:0048522 ~ positive regulation of cellular process

94

1.45

2.03E-04

   GOTERM_BP_3

GO:0009893 ~ positive regulation of metabolic process

51

1.53

2.64E-03

   GOTERM_BP_3

GO:0010604 ~ positive regulation of macromolecule metabolic process

48

1.54

3.02E-03

   GOTERM_BP_3

GO:0031325 ~ positive regulation of cellular

47

1.48

6.67E-03

   GOTERM_BP_3

GO:0009891 ~ positive regulation of biosynthetic

38

1.38

3.96E-02

   GOTERM_BP_3

GO:0031325 ~ positive regulation of nitrogen compound metabolic process

36

1.39

4.40E-02

Enrichment Score: 2.44

   GOTERM_BP_3

GO:0005996 ~ monosaccharide metabolic process

21

2.27

9.50E-04

   GOTERM_BP_3

GO:0005975 ~ carbohydrate metabolic process

37

1.67

2.63E-03

   GOTERM_BP_3

GO:0016051 ~ carbohydrate biosynthetic process

11

2.70

7.19E-03

   GOTERM_BP_3

GO:0044262 ~ cellular carbohydrate metabolic process

27

1.70

9.34E-03

  1. a |fold-change| ≥ 1.5 and P1(t) >0.999 at one or more time points
  2. b AhR enriched regions at 2 hrs with FDR < 0.01
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BMC Genomics

ISSN: 1471-2164

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