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Table 5 Functional enrichment analysis of differently regulateda genes with AhR enrichmentb using DAVID.

From: Integration of Genome-Wide Computation DRE Search, AhR ChIP-chip and Gene Expression Analyses of TCDD-Elicited Responses in the Mouse Liver

Category Team Gene Count Fold enrichment P-value
Enrichment Score: 7.34
   GOTERM_BP_3 GO:0006629 ~ lipid metabolic process 76 2.23 5.53E-11
   GOTERM_BP_3 GO:0044255 ~ cellular lipid metabolic process 53 2.23 7.80E-08
   GOTERM_BP_3 GO:0008610 ~ lipid biosynthetic process 32 2.30 2.28E-05
Enrichment Score:4.12
   GOTERM_BP_3 GO:0048523 ~ negative regulation of cellular process 94 1.60 4.46E-06
   GOTERM_BP_3 GO:0048519 ~ negative regulation of biological process 101 1.54 7.83E-06
   GOTERM_BP_3 GO:0031324 ~ negative regulation of cellular metabolic process 45 1.85 8.99E-05
   GOTERM_BP_3 GO:0051172 ~ negative regulation of nitrogen compound metabolic process 39 1.96 9.68E-05
   GOTERM_BP_3 GO:0009890 ~ negative regulation of biosynthetic process 40 1.86 2.33E-04
   GOTERM_BP_3 GO:0009892 ~ negative regulation of metabolic process 46 1.74 3.20E-04
   GOTERM_BP_3 GO:0010605 ~ negative regulation of macromolecule metabolic process 43 1.72 6.88E-04
Enrichment Score: 3.54
   GOTERM_BP_3 GO:0009410 ~ response to xenobiotic stimulus 8 10.59 3.54E-06
   GOTERM_BP_3 GO:0006805 ~ xenobiotic metabolic process 7 11.59 1.12E-05
   GOTERM_BP_3 GO:0018894 ~ dibenzo-p-dioxin metabolic process 3 19.86 7.31E-03
   GOTERM_BP_3 GO:0009404 ~ toxin metabolic process 3 11.92 2.28E-02
Enrichment Score: 2.70
   GOTERM_BP_3 GO:0051272 ~ positive regulation of call motion 9 4.58 6.00E-04
   GOTERM_BP_3 GO:0051270 ~ regulation of cell motion 15 2.84 7.55E-04
   GOTERM_BP_3 GO:0040017 ~ Positive regulation of locomotion 9 4.26 1.01E-03
   GOTERM_BP_3 GO:0030334 ~ regulation of cell migration 13 2.87 1.76E-03
   GOTERM_BP_3 GO:0040012 ~ regulation of locomotion 13 2.39 7.93E-03
   GOTERM_BP_3 GO:0040012 ~ regulation of localization 32 1.61 9.36E-03
Enrichment Score: 2.55
   GOTERM_BP_3 GO:0048518 ~ positive regulation of biological process 106 1.44 7.45E-05
   GOTERM_BP_3 GO:0048522 ~ positive regulation of cellular process 94 1.45 2.03E-04
   GOTERM_BP_3 GO:0009893 ~ positive regulation of metabolic process 51 1.53 2.64E-03
   GOTERM_BP_3 GO:0010604 ~ positive regulation of macromolecule metabolic process 48 1.54 3.02E-03
   GOTERM_BP_3 GO:0031325 ~ positive regulation of cellular 47 1.48 6.67E-03
   GOTERM_BP_3 GO:0009891 ~ positive regulation of biosynthetic 38 1.38 3.96E-02
   GOTERM_BP_3 GO:0031325 ~ positive regulation of nitrogen compound metabolic process 36 1.39 4.40E-02
Enrichment Score: 2.44
   GOTERM_BP_3 GO:0005996 ~ monosaccharide metabolic process 21 2.27 9.50E-04
   GOTERM_BP_3 GO:0005975 ~ carbohydrate metabolic process 37 1.67 2.63E-03
   GOTERM_BP_3 GO:0016051 ~ carbohydrate biosynthetic process 11 2.70 7.19E-03
   GOTERM_BP_3 GO:0044262 ~ cellular carbohydrate metabolic process 27 1.70 9.34E-03
  1. a |fold-change| ≥ 1.5 and P1(t) >0.999 at one or more time points
  2. b AhR enriched regions at 2 hrs with FDR < 0.01