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Table 1 Antibiotic susceptibility (mg/L) of B. cenocepacia J2315, resistant mutants and outbreak isolates

From: Spontaneous and evolutionary changes in the antibiotic resistance of Burkholderia cenocepacia observed by global gene expression analysis

Antibiotic clasBs Antibiotic name wild type
J2315
J2315-A
(AMKr)
J2315-M
(MERr)
J2315-T
(TMPr)
BCC
1616
BCC
1617
Beta-lactams Meropenem 7 13 15 6 30 7
  Imipenem 125 125 175 100 175 100
  Ceftazidime 10 30 40 10 60 5
  Cefotaxime 250 500 1200 250 >1500 15
  Aztreonam 250 500 1500 200 >1500 40
  Piperacillin 450 450 900 350 1500 40
Aminoglycosides Amikacin 200 450 200 200 450 900
  Gentamicin 700 5000 450 400 10000 >10000
  Tobramycin 150 500 300 125 1500 3000
Macrolides Azithromycin 50 40 40 30 200 >500
  Erythromycin 150 150 200 150 500 800
Folate synthesis inhibitors Trimethoprim/Sulfamethoxazole 30/150 20/100 30/150 150/750 10/50 20/100
Fluoroquinolones Ciprofloxacin 7 7 8 30 >50 13
  Levofloxacin 7 7 8 30 >50 13
Rifamycins Rifampicin 90 70 100 >200 60 80
Chloramphenicol Chloramphenicol 10 10 25 >400 15 15
Tetracyclines Tetracycline 60 70 180 120 160 >300