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Table 3 Differentially expressed B. cenocepacia genes selected from all conditions tested

From: Spontaneous and evolutionary changes in the antibiotic resistance of Burkholderia cenocepacia observed by global gene expression analysis

BExperimental condition from which the gene was selected

Fold change observed under each microarray condition

Gene name

Annotation

    

Exposure to amikacin

J2315 wt + 50 mg/L AMK

J2315-A

J2315-A + 50 mg/L AMK

J2315-A + 250 mg/L AMK

BCAL1233

Putative heat shock Hsp20-related protein

-

1.95

3.47

4.92

BCAL1234

Putative heat shock protein

-

-

3.00

4.43

BCAL1755

Conserved hypothetical protein

2.44

-

4.74

3.47

BCAL1756

Putative metal dependent phosphohydrolase

1.78

-

2.95

3.14

BCAL1919

ClpB heat-shock protein

-

-

-

3.20

BCAL2442

Chaperone protein HtpG

-

-

-

2.39

BCAL3146

60 kDa chaperonin 1

-

-

-

2.47

BCAL3147

10 kDa chaperonin 1

-

-

-

2.96

BCAL3148

Polyketide cyclase/dehydrase and lipid transport Family

-

2.14

3.27

1.95

BCAL3149

Outer membrane lipoprotein carrier protein LolA

-

2.86

4.22

2.31

BCAL3150

Putative exported protein

-

3.15

4.34

-

BCAL3151

putative transmembrane anti-sigma factor

-

2.76

4.43

2.31

BCAL3152

putative RNA polymerase sigma factor, ECF subfamily

-

2.94

4.77

3.40

BCAL3153

Putative lipoprotein

-

3.47

5.82

4.45

BCAL3270

Putative DnaK chaperone protein

-

-

-

2.76

BCAM0829a

RimL, Acetyltransferases, including N-acetylases of ribosomal proteins

-

2.51

2.46

2.14

BCAM0831

ABC transporter ATP-binding membrane protein

-

1.91

2.43

3.01

BCAS0637

60 kDa chaperonin 3

-

-

-

6.62

BCAS0638

10 kDa chaperonin 3

-

-

-

7.88

Exposure to meropenem

J2315 wt + 2 mg/L MER

J2315-M

J2315-M + 2 mg/L MER

J2315-M + 8 mg/L MER

BCAL0212

Putative phenylacetic acid degra-dation NADH oxidoreductase PaaE

-

-

-

3.32

BCAL0213

Phenylacetic acid degradation protein PaaD

-

-

-

6.61

BCAL0214

Phenylacetic acid degradation protein PaaC

-

-

-

3.14

BCAL0215

Phenylacetic acid degradation protein PaaB

-

8.01

6.48

3.81

BCAL0216

Phenylacetic acid degradation protein PaaA

-

14.83

10.03

6.79

BCAL0404

Phenylacetate-coenzyme A ligase

-

-

-

2.58

BCAL0405

Phenylacetic acid degradation protein PaaI

-

-

-

2.75

BCAL0406

Probable enoyl-CoA hydratase PaaG

-

6.28

-

3.63

BCAL0407

Beta-ketoadipyl CoA thiolase

-

-

-

4.48

BCAL0408

Putative phenylacetic acid degradation oxidoreductase paaZ

-

9.93

7.93

5.75

BCAL0409

Putative phenylacetic acid degra-dation enoyl-CoA hydratase PaaF

-

2.67

-

-

BCAL1804

Major Facilitator Superfamily protein

-

-3.45

-2.70

-1.85

BCAL1805

Putative sugar kinase

-

-4.76

-4.35

-2.22

BCAL1806

Conserved hypothetical protein

-

-14.29

-9.90

-5.26

BCAM1356

Putative gluconate 2-dehydrogenase subunit 3

-

-25.64

-29.50

-12.85

BCAM1357

Gluconate 2-dehydrogenase flavoprotein subunit

-

-7.14

-7.30

-5.52

BCAM1358

Gluconate 2-dehydrogenase cytochrome c subunit

-

-24.69

-25.38

-9.80

BCAM1710

Putative enoyl-CoA hydratase/isomerase

-

3.23

-

4.32

BCAM1711

Phenylacetate-coenzyme A ligase paaK

-

12.48

11.01

5.24

BCAM2165

Putative beta-lactamase, class A

53.35

-

60.30

60.62

BCAS0128

ABC transporter ATP-binding protein

-2.27

-2.04

-

-3.70

BCAS0129

Putative binding-protein-dependent transport system component

-2.56

-2.13

-

-4.98

BCAS0130

Putative ABC transporter substrate-binding protein

-2.94

-

-2.48

-6.25

BCAS0156

Beta-lactamase, class C

116.10

-

133.10

61.12

Exposure to trimethoprim sulfamethoxazole

J2315 wt + 10/50 mg/L TMP/SMX

J2315-T

J2315-T + 10/50 mg/L TMP/SMX

J2315-T + 60/300 mg/L TMP/SMX

BCAL0145

Adenosylhomocysteinase

1.77

-

-

2.26

BCAL0147

5,10-methylenetetrahydro-folate reductase

1.61

-

-

2.07

BCAM0186

Lectin

2.90

-

-

-

BCAM1869

Conserved hypothetical protein

-

-3.68

-4.13

-2.09

BCAM1870

N-acylhomoserine lactone synthase CepI

-

-15.48

-14.95

-3.51

BCAM1871

Conserved hypothetical protein

2.03

-14.88

-12.90

-3.73

BCAM2549

Multidrug efflux system outer membrane protein

-

138.20

111.80

35.80

BCAM2550

Multidrug efflux system transporter protein

-

108.80

103.60

30.79

BCAM2551

Multidrug efflux system transport protein CeoA

-

296.90

341.50

55.38

BCAM2552

Putative hydrolase

-

187.40

167.50

45.93

BCAM2554

LysR family regulatory protein

-

4.34

4.36

2.40

BCAS0292

Conserved hypothetical protein

3.41

-6.02

-4.03

-

BCAS0293

Nematocidal protein AidA

8.56

-6.02

-5.65

-2.67

BCAS0409

ZmpA

1.99

-

-

-

Exposure to chlorpromazine

J2315 wt + 0.05 mM CPZ

J2315 wt + 0.05 mM CPZ + 50 mg/L AMK

  

BCAL1233

Putative heat shock Hsp20-related protein

-

2.98

  

BCAL1234

Putative heat shock protein

-

2.40

  

BCAL1755

Conserved hypothetical protein

-

2.07

  

BCAL1756

Conserved hypothetical protein

2.04

1.82

  

BCAM0923

Putative lipoprotein

11.00

11.33

  

BCAM0924

Two-component regulatory system, response regulator protein

4.85

4.63

  

BCAM0925

Multidrug efflux system outer membrane protein

12.80

16.51

  

BCAM0926

Multidrug efflux system transporter protein

17.75

27.45

  

BCAM0927

Multidrug efflux system transport protein

13.75

22.43

  

BCAM2186

Putative macrolide-specific efflux system transport protein

1.96

2.04

  

BCAM2187

Putative ThiJ/PfpI family protein

1.60

2.02

  

BCAS0167

Squalene-hopene cyclase

4.36

5.35

  

BCAS0168

TetR family regulatory protein

2.33

2.81

  

BCAS0638

10 kDa chaperonin 3

 

4.18

  
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