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Table 5 Selected genes differentially expressed in the recent B. cenocepacia outbreak strains BCC1616 and BCC1617 compared to B. cenocepacia J2315

From: Spontaneous and evolutionary changes in the antibiotic resistance of Burkholderia cenocepacia observed by global gene expression analysis

Functional class and gene name

Annotation

Fold change in expression1)

  

BCC1616

BCC1617

Motility and chemotaxis

  

BCAL0113

B-type flagellar hook-associated protein 2

-18.80

-11.33

BCAL0114

flagellin (type II)

-38.91

-24.51

BCAL0126

chemotaxis protein MotA

-3.22

-2.41

BCAL0127

chemotaxis protein MotB

-5.68

-

BCAL0128

chemotaxis two-component response regulator CheY

-6.76

-2.95

BCAL0129

chemotaxis two-component sensor kinase CheA

-6.80

-3.26

BCAL0130

chemotaxis protein CheW

-3.11

-2.82

BCAL0521

flagellar FliJ protein

-4.31

-3.28

BCAL0576

flagellar hook-associated protein 1 (HAP1)

-11.57

-5.38

BCAL0577

flagellar hook-associated protein 3 (HAP3)

-14.33

-6.21

BCAL0762

putative methyl-accepting chemotaxis protein

-3.32

-2.99

BCAM1503

putative methyl-accepting chemotaxis protein

-16.92

-9.90

BCAL1662

putative methyl-accepting chemotaxis protein

-4.98

-2.57

BCAM1804

methyl-accepting chemotaxis protein

-12.56

-6.71

BCAM2564

putative aerotaxis receptor

-6.45

-3.52

Cable pilus biosynthesis

  

BCAM2758

two-component regulatory system, sensor kinase protein

-2.19

-2.63

BCAM2759

putative minor pilin and initiator

-

-3.69

BCAM2760

putative outer membrane usher

-2.15

-2.96

BCAM2761

giant cable pilus

-2.97

-6.90

BCAM2762

giant cable pilus chaperone protein

-4.44

-10.00

Transport, efflux and antimicrobial resistance

  

BCAL1674

multidrug efflux system AmrA protein

-

2.49

BCAL1756

Putative metal dependent phosphohydrolase

-

1.97

BCAM2165

putative beta-lactamase, class A

2.45

-

BCAS0081

ABC transporter ATP-binding membrane protein

35.39

33.37

BCAS0082

Hydrolase of the alpha/beta superfamily

41.13

30.37

Restriction modification

  

BCAL0414_J_1

type I modification component of restriction-modification system (pseudogene)

23.04

24.84

BCAL0418

type I restriction enzyme specificity protein

12.59

10.77

BCAL0420

type I restriction component of type I restriction-modification system

3.79

3.04

Transposition

  

BCAL0044

putative transposase

3.75

2.91

BCAM2637

putative transposase

7.42

3.04

Aromatic hydrocarbon catabolism

  

BCAL0212

putative phenylacetic acid degradation NADH oxidoreductase PaaE

2.29

-

BCAL0213

phenylacetic acid degradation protein PaaD

5.19

-

BCAL0215

phenylacetic acid degradation protein PaaB

3.31

-

BCAL0216

phenylacetic acid degradation protein PaaA

3.06

-

BCAL0405

phenylacetic acid degradation protein PaaI

2.49

-

BCAL0406

probable enoyl-CoA hydratase PaaG

2.54

-

BCAL0407

beta-ketoadipyl CoA thiolase

4.38

-

BCAM1711

phenylacetate-coenzyme A ligase paaK

3.44

-

BCAM0058

3-oxoadipate CoA-transferase subunit A

-

61.45

BCAM0059

3-oxoadipate CoA-transferase subunit B

-

70.43

BCAM0060

3-carboxy-cis, cis-muconate cycloisomerase

-

30.44

BCAM0061

putative 3-oxoadipate enol-lactonase I

-

37.36

BCAM0062

4-carboxymuconolactone decarboxylase

-

48.08

BCAM0063

putative 4-hydroxybenzoate transporter

-

5.79

BCAM2568

putative beta-ketoadipyl CoA thiolase

-

35.88

BCAM2569

IclR family regulatory protein

-

13.08

Miscellaneous genes

  

BCAL0297

putative thiamine biosynthesis oxidoreductase

5.69

2.50

BCAL1104

thiamine biosynthesis protein

4.24

3.01

BCAL1756

Putative metal dependent phosphohydrolase

-

1.97

BCAL3152

putative RNA polymerase sigma factor, ECF subfamily

5.26

-8.93

BCAL3153

putative lipoprotein

6.89

-13.04

BCAM0186

lectin

7.89

-

BCAS0125

conserved hypothetical protein

31.75

-

BCAS0126

MarR family regulatory protein/acetyltransferase

9.18

-

BCAS0292

conserved hypothetical protein

3.98

-

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BMC Genomics

ISSN: 1471-2164

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