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Table 5 Selected genes differentially expressed in the recent B. cenocepacia outbreak strains BCC1616 and BCC1617 compared to B. cenocepacia J2315

From: Spontaneous and evolutionary changes in the antibiotic resistance of Burkholderia cenocepacia observed by global gene expression analysis

Functional class and gene name Annotation Fold change in expression1)
   BCC1616 BCC1617
Motility and chemotaxis   
BCAL0113 B-type flagellar hook-associated protein 2 -18.80 -11.33
BCAL0114 flagellin (type II) -38.91 -24.51
BCAL0126 chemotaxis protein MotA -3.22 -2.41
BCAL0127 chemotaxis protein MotB -5.68 -
BCAL0128 chemotaxis two-component response regulator CheY -6.76 -2.95
BCAL0129 chemotaxis two-component sensor kinase CheA -6.80 -3.26
BCAL0130 chemotaxis protein CheW -3.11 -2.82
BCAL0521 flagellar FliJ protein -4.31 -3.28
BCAL0576 flagellar hook-associated protein 1 (HAP1) -11.57 -5.38
BCAL0577 flagellar hook-associated protein 3 (HAP3) -14.33 -6.21
BCAL0762 putative methyl-accepting chemotaxis protein -3.32 -2.99
BCAM1503 putative methyl-accepting chemotaxis protein -16.92 -9.90
BCAL1662 putative methyl-accepting chemotaxis protein -4.98 -2.57
BCAM1804 methyl-accepting chemotaxis protein -12.56 -6.71
BCAM2564 putative aerotaxis receptor -6.45 -3.52
Cable pilus biosynthesis   
BCAM2758 two-component regulatory system, sensor kinase protein -2.19 -2.63
BCAM2759 putative minor pilin and initiator - -3.69
BCAM2760 putative outer membrane usher -2.15 -2.96
BCAM2761 giant cable pilus -2.97 -6.90
BCAM2762 giant cable pilus chaperone protein -4.44 -10.00
Transport, efflux and antimicrobial resistance   
BCAL1674 multidrug efflux system AmrA protein - 2.49
BCAL1756 Putative metal dependent phosphohydrolase - 1.97
BCAM2165 putative beta-lactamase, class A 2.45 -
BCAS0081 ABC transporter ATP-binding membrane protein 35.39 33.37
BCAS0082 Hydrolase of the alpha/beta superfamily 41.13 30.37
Restriction modification   
BCAL0414_J_1 type I modification component of restriction-modification system (pseudogene) 23.04 24.84
BCAL0418 type I restriction enzyme specificity protein 12.59 10.77
BCAL0420 type I restriction component of type I restriction-modification system 3.79 3.04
Transposition   
BCAL0044 putative transposase 3.75 2.91
BCAM2637 putative transposase 7.42 3.04
Aromatic hydrocarbon catabolism   
BCAL0212 putative phenylacetic acid degradation NADH oxidoreductase PaaE 2.29 -
BCAL0213 phenylacetic acid degradation protein PaaD 5.19 -
BCAL0215 phenylacetic acid degradation protein PaaB 3.31 -
BCAL0216 phenylacetic acid degradation protein PaaA 3.06 -
BCAL0405 phenylacetic acid degradation protein PaaI 2.49 -
BCAL0406 probable enoyl-CoA hydratase PaaG 2.54 -
BCAL0407 beta-ketoadipyl CoA thiolase 4.38 -
BCAM1711 phenylacetate-coenzyme A ligase paaK 3.44 -
BCAM0058 3-oxoadipate CoA-transferase subunit A - 61.45
BCAM0059 3-oxoadipate CoA-transferase subunit B - 70.43
BCAM0060 3-carboxy-cis, cis-muconate cycloisomerase - 30.44
BCAM0061 putative 3-oxoadipate enol-lactonase I - 37.36
BCAM0062 4-carboxymuconolactone decarboxylase - 48.08
BCAM0063 putative 4-hydroxybenzoate transporter - 5.79
BCAM2568 putative beta-ketoadipyl CoA thiolase - 35.88
BCAM2569 IclR family regulatory protein - 13.08
Miscellaneous genes   
BCAL0297 putative thiamine biosynthesis oxidoreductase 5.69 2.50
BCAL1104 thiamine biosynthesis protein 4.24 3.01
BCAL1756 Putative metal dependent phosphohydrolase - 1.97
BCAL3152 putative RNA polymerase sigma factor, ECF subfamily 5.26 -8.93
BCAL3153 putative lipoprotein 6.89 -13.04
BCAM0186 lectin 7.89 -
BCAS0125 conserved hypothetical protein 31.75 -
BCAS0126 MarR family regulatory protein/acetyltransferase 9.18 -
BCAS0292 conserved hypothetical protein 3.98 -