The size spectrum of SVs identifiable to different methods. No method can identify SVs of all different sizes. The black bars indicate the size ranges of discoverable SVs by different methods, which include the dbSNP database, the high-resolution array CGH (hr-aCGH), the read-pair (RP) method with fosmid, 454, and Solexa sequencing, and the split-read analysis. The range of detectable indels by RP depends on three values: the mean and the standard deviation between the distances of mapped read pairs and the multiple coefficient of s.d. for significance. These triple values are (40 kb, 2.8 kb, 3), (1 kb, 0.8 kb, 3), (250 bp, 25 bp, 6) for fosmid, 454, and Solexa sequencing, respectively.