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Figure 4 | BMC Genomics

Figure 4

From: A gene-rich, transcriptionally active environment and the pre-deposition of repressive marks are predictive of susceptibility to KRAB/KAP1-mediated silencing

Figure 4

Characterization of the chromatin environments of the matched gene groups with respect to active histone marks. (A) The levels of specific posttranslational histone modifications around the promoters of the different gene groups were calculated over different DNA intervals ranging from 1 kb to 1 Mb. The gene groups included group 1: "long-range repression", group 2: "limited repression" and group 3: "absence of repression" and ROC curve analyses was employed. Briefly, the illustrated heat maps, contain squares giving the relative abundance of the studied histone mark. 1 is scored when the modification is enriched in the gene group when compared to a control group, while 0 indicates depletion of the mark. 0.5 is scored when there is no difference. Non-central chi-square statistical analysis compared differences between the repressible group 1 and the non-repressible group 3. P-Value Legend: * p < 0.05; ** p < 0.01. The histone modifications in the analysis included H3K27ac, H2BK5me1, H3K4me1, H3K4me3, H3K36me3, H4K20me1, which are mostly found within active chromatin. (B) Relevant histograms representing the relative H3K4me3 and H3K36me3 values over 100 kb and 1 Mb, which reached statistically relevant differences when all three gene groups were compared.

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