Replication-directed translocations. Whole genome alignments of Brachyspira species chromosomes. Sequences were permutated to set the origin of replication according to GC-skew. Red dots are conserved regions oriented in the same direction in both genomes and blue dots have an opposite orientation. a, B. intermedia PWS/AT versus B. hyodysenteriae WA1. b, B. intermedia PWS/AT versus B. murdochii 56-150T. c, B. intermedia PWS/AT versus B. pilosicoli 95/1000. d, B. murdochii 56-150T versus B. pilosicoli 95/1000.