A codon substitution model that incorporates the effect of the GC contents, the gene density and the density of CpG islands of human chromosomes

Table 4 Correlation coefficients squared (r²) between ln (Rate ×10⁸) and chromosomal features

Type	r² obtained by single regression to Grantham distance	Adjusted r² obtained by multiple regression to Grantham distance, GC content, gene density, CpG island density
CpG to TpG	0.051	0.089
TpG to CpG	0.154	0.224
non-CpG Transition	0.122	0.182
Transversion	0.054	0.190

ISSN: 1471-2164