Table 2 Dominating functions of the Prediction signature
Function | Number of molecules from signature | Molecule names | Most prominent sub functions |
|---|---|---|---|
small molecule biochemistry | 39 | ABHD5, ACLY, ALDH18A1, BLMH, CD86, CSGALNACT2, CYP51A1, DHCR24, DHCR7, DNAJC5, FAS, FASN, FDXR, FOXO4, GLRX, GNPNAT1, HMGCR, HMOX1, IRS2, LPAR1, LY96, MGST3, MTR, NQO1, PASK, PDE1B, PINK1, PMM2, RENBP, RXRA, SLC25A32, SLC37A4, SLC5A6, SMPD4, SQLE, SREBF2, ST3GAL6, TLR6, TMEM55A | Metabolism (24), biosynthesis (15), modification (12), synthesis (11) |
cell death | 33 | CD33, DDX19A, DHCR24, DNAJB9, DNAJC5, FAS, FASN, FDXR, FOXO4, GLRX, GNPNAT1, GSR, HIST1H1C, HMGB3, HMOX1, IRS2, LPAR1, MAP2K1, MAPK13, NQO1, PAWR, PDE1B, PHLDA3, PINK1, PPM1D, RXRA, SERBP1, SPRY2, STK17B, TLR6, TNFRSF10C, TP53INP1, TXNRD1 | Apoptosis (30), cell death (13) |
lipid metabolism | 25 | ABHD5, ACLY, CYP51A1, DHCR24, DHCR7, FAS, FASN, FDXR, FOXO4, HMGCR, HMOX1, IRS2, LPAR1, LY96, MGST3, PASK, RENBP, RXRA, SLC37A4, SMPD4, SQLE, SREBF2, ST3GAL6, TLR6, TMEM55A | Metabolism (18), synthesis (11), modification (11) |
hematological system development | 18 | CARM1, CD33, CD86, FAS, FOXO4, HMGB3, HMGCR, HMOX1, IRS2, LY96, NBR1, NQO1, PAWR, PIK3AP1, PPM1D, STK17B, TP53INP1, VAMP3 | Proliferation (10), quantity (7) |
cell cycle | 18 | ABHD5, ANAPC5, DNAJB4, DTD1, FAS, FASN, FOXO4, GDF11, HBP1, HMOX1, IRS2, MAP2K1, PAWR, PPM1D, RXRA, SFPQ, SPRY2, TP53INP1 | Cell cycle progression (13), G2 phase (5) |
molecular transport | 17 | ABHD5, DNAJC5, FAS, FOXO4, HMOX1, LPAR1, MTR, NQO1, PASK, PINK1, RENBP, RXRA, SLC25A32, SLC37A4, SLC5A6, SREBF2, TLR6 | Accumulation (9), quantity (5) |
cellular growth and proliferation | 16 | CD33, CD86, FAS, GNPNAT1, HMOX1, IRS2, LPAR1, LY96, MAP2K1, PAWR, PIK3AP1, PPM1D, RXRA, SPRY2, STK17B, TP53INP1 | Proliferation (16), growth (4) |
carbohydrate metabolism | 15 | ABHD5, ACLY, CSGALNACT2, FAS, FASN, FUCA2, GNPNAT1, IRS2, LY96, NQO1, PMM2, RENBP, SLC37A4, ST3GAL6, TMEM55A | Metabolism (9), biosynthesis (5) |