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Table 2 Dominating functions of the Prediction signature

From: A genomic biomarker signature can predict skin sensitizers using a cell-based in vitro alternative to animal tests

Function Number of molecules from signature Molecule names Most prominent sub functions
small molecule biochemistry 39 ABHD5, ACLY, ALDH18A1, BLMH, CD86, CSGALNACT2, CYP51A1, DHCR24, DHCR7, DNAJC5, FAS, FASN, FDXR, FOXO4, GLRX, GNPNAT1, HMGCR, HMOX1, IRS2, LPAR1, LY96, MGST3, MTR, NQO1, PASK, PDE1B, PINK1, PMM2, RENBP, RXRA, SLC25A32, SLC37A4, SLC5A6, SMPD4, SQLE, SREBF2, ST3GAL6, TLR6, TMEM55A Metabolism (24), biosynthesis (15), modification (12), synthesis (11)
cell death 33 CD33, DDX19A, DHCR24, DNAJB9, DNAJC5, FAS, FASN, FDXR, FOXO4, GLRX, GNPNAT1, GSR, HIST1H1C, HMGB3, HMOX1, IRS2, LPAR1, MAP2K1, MAPK13, NQO1, PAWR, PDE1B, PHLDA3, PINK1, PPM1D, RXRA, SERBP1, SPRY2, STK17B, TLR6, TNFRSF10C, TP53INP1, TXNRD1 Apoptosis (30), cell death (13)
lipid metabolism 25 ABHD5, ACLY, CYP51A1, DHCR24, DHCR7, FAS, FASN, FDXR, FOXO4, HMGCR, HMOX1, IRS2, LPAR1, LY96, MGST3, PASK, RENBP, RXRA, SLC37A4, SMPD4, SQLE, SREBF2, ST3GAL6, TLR6, TMEM55A Metabolism (18), synthesis (11), modification (11)
hematological system development 18 CARM1, CD33, CD86, FAS, FOXO4, HMGB3, HMGCR, HMOX1, IRS2, LY96, NBR1, NQO1, PAWR, PIK3AP1, PPM1D, STK17B, TP53INP1, VAMP3 Proliferation (10), quantity (7)
cell cycle 18 ABHD5, ANAPC5, DNAJB4, DTD1, FAS, FASN, FOXO4, GDF11, HBP1, HMOX1, IRS2, MAP2K1, PAWR, PPM1D, RXRA, SFPQ, SPRY2, TP53INP1 Cell cycle progression (13), G2 phase (5)
molecular transport 17 ABHD5, DNAJC5, FAS, FOXO4, HMOX1, LPAR1, MTR, NQO1, PASK, PINK1, RENBP, RXRA, SLC25A32, SLC37A4, SLC5A6, SREBF2, TLR6 Accumulation (9), quantity (5)
cellular growth and proliferation 16 CD33, CD86, FAS, GNPNAT1, HMOX1, IRS2, LPAR1, LY96, MAP2K1, PAWR, PIK3AP1, PPM1D, RXRA, SPRY2, STK17B, TP53INP1 Proliferation (16), growth (4)
carbohydrate metabolism 15 ABHD5, ACLY, CSGALNACT2, FAS, FASN, FUCA2, GNPNAT1, IRS2, LY96, NQO1, PMM2, RENBP, SLC37A4, ST3GAL6, TMEM55A Metabolism (9), biosynthesis (5)
  1. Dominating functions in the molecular signature. 184 of the 200 molecules were functionally investigated, using IPA. Only functions populated by 15 or more genes were included in the present study.