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Table 3 List of reference chemicals used in assay development

From: A genomic biomarker signature can predict skin sensitizers using a cell-based in vitro alternative to animal tests

Compound Abbreviation Potency LLNA HMT1 HPTA1
Sensitizers      
2,4-Dinitrochlorobenzene DNCB Extreme [15] + [15]   
Oxazolone OXA Extreme [15] + [15]   
Potassium dichromate PD Extreme [14] + [14] + +
Kathon CG (MC/MCI) KCG Extreme [14, 45] + [14, 46]   
Formaldehyde FA Strong [15] + [15] + +
2-Aminophenol 2AP Strong [46] + [47]   
2-nitro-1,4-Phenylendiamine NPDA Strong [46] + [47]   
p-Phenylendiamine PPD Strong [47] + [48] + +
Hexylcinnamic aldehyde HCA Moderate [15] + [15]   
2-Hydroxyethyl acrylate 2HA Moderate [46] + [47]   +
2-Mercaptobenzothiazole MBT Moderate [46] + [47] + +
Glyoxal GO Moderate [46] + [47] +  
Cinnamaldehyde CALD Moderate [47] + [48] + +
Isoeugenol IEU Moderate [47] + [48]   +
Ethylendiamine EDA Moderate [14] + [14]   
Resorcinol RC Moderate [48] + [49] - +
Cinnamic alcohol CALC Weak [46] + [48]   
Eugenol EU Weak [47] + [48]   +
Penicillin G PEN G Weak [47] + [48] +  
Geraniol GER Weak [14] + [14] - +
Non-sensitizers      
1-Butanol BUT   - [50]   
4-Aminobenzoic acid PABA   - [51] - +
Benzaldehyde BA   - [52]   
Chlorobenzene CB   - [14]   
Diethyl phthalate DP   - [48]   
Dimethyl formamide DF   - [46]   
Ethyl vanillin EV   - [52]   
Glycerol GLY   - [48]   
Isopropanol IP   - [48]   
Lactic acid LA   - [14]   
Methyl salicylate MS   - [14] -  
Octanoic acid OA   - [53]   
Propylene glycol PG   - [51]   
Phenol PHE   - [53] -  
p-Hydroxybenzoic acid HBA   - [54]   
Potassium permanganate PP   -   
Salicylic acid SA   - [14] -  
Sodium dodecyl sulphate SDS   +2 [14, 53] -  
Tween 80 T80   - [20]   +
Zinc sulphate ZS   +2 [55]   
  1. List of sensitizers and non-sensitizers used in assay development. 1) HMT, Human Maximization Test; HPTA, Human Patch Test Allergen. Information is derived from [17]. 2) False positives in LLNA.