Transcriptional responses to glucose in Saccharomyces cerevisiae strains lacking a functional protein kinase A

BMC Genomics

Table 4 Involvement of PKA in the transcriptional regulation of different classes of genes controlled by glucose

Class	Transcriptional effect	Glucose added to strain		No glucose added	Representative genes
		PKA⁺	PKA^-	PKA activated
1	Induction	+	+	-	PFK1, ENO2
	Repression	+	+	-	CRC1, PCK1, MLS1
2	Induction	+	-	+	ARG3, THR4
	Repression	+	-	+	GRX2, PEP4
3	Induction	+	+	+	HXT3, RPL7A, HOR2
	Repression	+	+	+	ACS1, ADY2, CIT3
4	Induction	+	-	-	SDT1, STR3
	Repression	+	-	-	HXT6, MDH1

The presence or absence of transcriptional response after addition of glucose to yeast strains with or without PKA activity is indicated by + or -. The column labelled "No glucose added" shows the transcriptional response when PKA is activated through an increase in cAMP that does not involve the presence of glucose [5].

ISSN: 1471-2164