Figure 7
Immunoblot illustrating inflammatory signalling responses in 3 isolates with low and high basal expression of MMP-1 (labelled isolates 1, 2, 3 and 4, 5, 6 respectively). Low = low basal expressers and High = high basal expressers. Time in hours for each group of low and high basal expressers is given at the top of the figure. (a) IκBα signalling over 3.5 hours after the addition of an inflammatory mediator cocktail containing 10 ng/ml each of TNF-α, Il-1β and Il-8. (b) Phosphorylated IκBα signalling over the time course. (c) ICAM signalling over the time course. Both the high expressers and low expressers show similar levels of IκBα, phospho- IκBα and ICAM over the time course.