GenMAPPs showing functions and genes significantly changed by OPP in the liver. (A) Genes up-regulated in the liver fatty acid beta oxidation pathway. This GenMAPP represents an overview of three individual fatty acid beta oxidation GenMAPPs, and shows the up-regulation of fatty acid beta oxidation genes such as acetyl-CoA dehydrogenase (Acadl), acyl-CoA dehydrogenase (Acads) and hydroxyacyl-CoA dehydrogenases (Hadhb, Hadhsc). (B) Genes down-regulated in the liver cholesterol biosynthesis pathway. Note that the fold changes for most of the genes in this GenMAPP were negative, indicating down-regulation, even for genes which were not selected as significantly different based on the selection criteria used. Also note that Hmgcr which encodes for 3-hydroxy-3-methylglutaryl-CoA reductase, an enzyme inhibited by cholesterol-lowering statins, showed a negative fold change as well, although the value was not statistically significant.