Figure 5
From: Differential transcriptomic profiles effected by oil palm phenolics indicate novel health outcomes
GenMAPPs showing functions and genes significantly changed by OPP in the heart. (A) Genes up-regulated and down-regulated in the heart tricarboxylic acid (TCA) cycle. Pdk4, which is involved in fuel selection in the heart by inhibiting pyruvate dehydrogenase and preventing the metabolic shift in ageing hearts from fatty acid beta oxidation towards glycolysis, was up-regulated, while other genes such as Mdh1, Shdb, Suclg1, Sucla2 and Dld were down-regulated. (B) Ucp3, a gene encoding an uncoupling protein which protects against mitochondrial oxidative damage by reducing the production of reactive oxygen species (ROS), was up-regulated, while other genes which encode adenine nucleotide translocators and proteins in Complex I, Complex II and Complex V in the electron transport chain were down-regulated.