Figure 1
From: Analysis of human meiotic recombination events with a parent-sibling tracing approach
Different types of pedigrees are required for determining meiotic recombination sites by various methods. (A) Three-generation pedigrees are required for the identity by descent (IBD) method, and (B) complete two-generation pedigree for the parent-sibling tracing (PST) method. In the IBD method, the 'A' and 'B' allele in child 1 were required to originate from grandmother and grandfather, respectively. In PST approach, the paternal genotype was 'Aa' and the maternal genotype was 'AA', children with 'Aa' and 'aa' were coded as "0: not identical between siblings". If both children were 'Aa' and 'Aa' [or ('AA' and 'AA')], they were coded as "1: identical between siblings", (identical genotype origin for both children). Abbreviations: GF, grandfather; GM, grandmother; FA, father; MO, mother; CH1 and CH2, child 1 and child 2.